Certain bacterial species appear more common in gut microbiomes of individuals with MS, coinciding with inflammation-related gene expression in host blood.
The collaboration will use Transplant Genomics' TruGraf test for post-kidney transplant monitoring to try to personalize immunosuppression therapies.
The company now offers three CE-marked autoantibody assays — for BICD2, Scl70, and CENP-B — that can be used for clinical management of the condition.
A team of scientists and entrepreneurs is trying to build a company around a dataset from a large multi-omics clinical study funded by Genome Canada.
The funding will support development of tests that detect cell-free DNA methylation patterns indicative of disease in specific tissues of the body.
The company said it has enlisted 23 academic and medical institutions to supply patient samples that will support the validation and launch of its tests.
Researchers identified a common variant in a long non-coding RNA that may contribute to inflammation seen in patients diagnosed with celiac disease.
A mutation uncovered in a Belgian family through genetic analysis disrupts pyrin protein regulation to lead to an autoinflammatory disease.
The firm has not disclosed the specific disease the test will address but has determined this space represents the best opportunity for its array technology.
The new study in NEJM describes six families that share a disorder caused by mutations in IKAROS, a protein that plays a role in immune cell development.
The partners will collaborate on point-of-care tests for validating the identity and activity of biologics and biosimilars.
The approach can increase CpG coverage about 18-fold by inferring from existing data to predict methylation of sites outside those covered on the arrays themselves.
Under the terms of the deal, IQuity's autoimmune disease diagnostics will be made available through Diatherix's CLIA-certified clinical laboratory.
The Dutch firm plans to develop a complete, CE-marked pipeline for NGS-base HLA typing, from DNA amplification to software analysis.
After scrapping initial plans to develop a diagnostic instrument, the company has been working for several years to advance its single-cell droplet platform for targeted drug development.
The Swedish firm, a spinout of Lund University, will evaluate the array-based blood tests to confirm, rule out, and monitor the autoimmune disease.
The results are the first showing that a vaginal delivery microbiome can be partially replicated in C-section babies, though it is yet unclear whether this will impact their health.
At the Personalized Medicine World Conference, researchers talked about how understanding the microbiome is leading to therapies aimed at keeping it healthy.
A genome-wide association study involving tens of thousands of Asian individuals revealed new and known associations for systemic lupus erythematosus.
The company presented new data at a meeting last week showing that Vectra DA predicted whether patients would do better on one or the other of two possible second-line therapies.
In PLOS this week: a sequencing-based screen of Lyme disease-causing pathogen, the range of animals bitten by Anopheles darling mosquitoes in Peru, and more.
An NC State researcher is exploring the use of CRISPR-Cas3 as an anti-microbial, Gizmodo reports.
The Earth BioGenome Project plans to sequence all life on Earth, according to ScienceInsider.
For those who are concerned about Trump administration actions related to science, a new column in Scientific American has suggestions for ways to fight back.