Tapping into genetic variation in the CETP gene, investigators explored blood lipid and disease effects of high-density cholesterol changes.
In a study of nearly 45,000 people, researchers found that two variants in LPA each increase aortic stenosis risk by about a third, and about twofold in combination.
A pair of studies has uncovered additional loci and ancestry-specific variants that are associated with plasma lipid levels and coronary artery disease risk.
The company is offering introductory pricing on Helix services for heart health and weight loss, and has shifted its flagship program from a yearly subscription to a monthly option.
A Johns Hopkins team reported its finding in JAMA Cardiology, backed by SNP array data from 21,870 participants culled from several large cardiovascular studies.
People with atherosclerotic cardiovascular disease have increased levels of certain bacteria in their stool, a metagenome-wide association study has found.
Exome sequences for thousands of people revealed rare, inherited mutations and de novo mutations in a significant subset of congenital heart disease cases.
Researchers found variants associated with coronary artery disease and migraine risk at three loci in a genome-wide association study, with opposing directional effects at two index SNPs.
Results from a randomized clinical trial known as GIFT suggest that genotype-guided warfarin dosing is linked to fewer adverse events than clinical dosing.
The researchers believe that the discovery of the genetic loci linked to T2D and CHD will lead to therapeutic opportunities to lower the risk of both diseases.
Data from several large cohorts suggests that a variant in LILRB5 may produce a propensity for muscle pain or myalgia, upping the risk of statin intolerance.
Variants in CETP-inhibitor and statin target genes helped investigators untangle complex ties between low-density lipoprotein levels and cardiovascular events.
The latest offering puts the genetic testing company on the path toward becoming what it calls a preventive health service company.
Researchers have used the gene-editing tool CRISPR/Cas9 to correct a mutation linked to hypertrophic cardiomyopathy in embryos.
UK and Swedish researchers used a Mendelian randomization approach to study the association between serum calcium and heart disease and heart attack risk.
Using data from the UK Biobank, a Harvard Medical School-led team of researchers has uncovered 15 new loci associated with coronary artery disease.
The two firms are offering a combined genetic disease risk and pharmacogenomic analysis that covers 49 conditions and about 220 medications.
A Canadian research team has reported beta-blockers alter the gene expression changes that take place in a mouse model of heart failure.
The international team says its findings may explain the evolutionary reasons for the maintenance of coronary artery disease in human populations.
Researchers found that certain somatic mutations in blood stem cells elevate coronary heart disease risk, likely by accelerating atherosclerosis.
Lawmakers have asked four direct-to-consumer genetic testing companies to explain their privacy policies and security measures, according to Stat News.
The Trump Administration has proposed a plan to reorganize the federal government, the Washington Post reports.
In Science this week: genetic overlap among many psychiatric disorders, and more.
The Economist writes that an increasing number of scientific journals don't do peer review.