BD and Tyrian ended their partnership to develop a point-of-care diagnostic for active tuberculosis because of an inability to consistently detect Tyrian's lead protein biomarker in clinical samples at high enough sensitivity and specificity levels.
The company said it is working with the City of Hope to investigate the vector-based delivery of an anti-HIV RNA cocktail composed of pHIV7, an shRNA targeting an exon in HIV-1 tat/rev, and a Tar decoy.
Exiqon said that it has achieved several milestones in a collaboration with Tacere Therapeutics, including the completion of a series of customizable assays for the detection of therapeutic shRNAs currently under development through a partnership between Tacere and Pfizer.
The $600,000 award also strengthens Inviragen's ties to UW-Madison. The company's CSO maintains an academic appointment and a research lab within the School of Veterinary Medicine, which has collaborated with Inviragen on other projects.
In an interview with Pharmacogenomics Reporter this week, Hakan Sakul provided a snapshot of Pfizer's efforts in personalized medicine, the company's stance on regulatory issues, and its overall focus on "omics"-guided medicine.
The $200,000 grant also dovetails with an existing grant under which the University of Oklahoma Health Sciences Center and Pure Vaccine Solutions aim to look for new disease-specific biomarkers for West Nile virus. Both Receptor Logic and Pure Vaccine Solutions are portfolio companies of VC shop Emergent Technologies.
This is the second vaccine-development partnership struck between Advaxis and City of Hope in as many years, further cementing an ongoing and mutually beneficial research partnership between the company and the cancer research center, according to an Advaxis executive.
Schering-Plough owns the IP rights to the drug-response marker and is contemplating further developing and marketing a diagnostic based on it that could accompany its current marketed interferon-based HCV treatment.