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Bioinformatics

Researchers from Kaiser Permanente and the National Cancer Institute who co-tested nearly 600,000 women using Pap and HPV tests over five years have concluded that such testing doesn't lead to an excess of HPV positive women requiring lengthy follow-up.

The grant will support the development of the firm's pressure cycling technology in sample prep for microbiome studies.

NKT licensed the IP from Beth Israel Deaconess Medical Center, Dana-Farber Cancer Institute, and Massachusetts General Hospital. As a result, each of the Harvard Med-affiliated institutes has been awarded an undisclosed equity stake in the company.

Although the developers note that the protocol particularly benefits the sequencing of AT-rich genomes, they say that it is also quicker than the standard method, which requires PCR amplification, and "should be used routinely to prepare libraries for Genome Analyzer sequencing."

Hologic joins Qiagen as the only firm to receive FDA clearance to sell an HPV molecular diagnostic test in the US. Hologic's shares went up and Qiagen's went down following the news.

Using bioinformatics, an American research team has found that more than a dozen species of Rickettsia bacteria — both pathogenic and non-pathogenic — share a conserved type IV secretion system.

The Center for Translational Molecular Medicine is funding eight research projects targeting cancer, cardiovascular, neurodegenerative, and infectious diseases.

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Chronix Biomedical, Rosetta Genomics, National Institute of General Medical Sciences, National Center for Genome Resources, Beyond Batten Disease Research Foundation, and more ...

The Xpert MRSA/SA Blood Culture test is Cepheid's sixth test to receive a license from Health Canada.

Funding Update for Mar 10, 2009

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NIH Array-Related Grants Awarded Dec. 23, 2008 — March 10, 2009

Chronix Biomedical said that the current study confirms its previous research showing that CNAs can identify the presence of certain diseases in blood samples months to years before clinical symptoms appear.

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Sequencing-Related Papers of Note, Feb. 2009

The company last month presented data showing that the test could be used to detect cancer, but more work is needed to refine the test so that it can distinguish between different types of malignancies.

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DNAPrint, Laboratory Corporation of America, Duke University, Lab21, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Diseases and Stroke, and more …

Lab21 gains access to a phage amplification technology that it is being used to develop rapid tests for active and drug-resistant tuberculosis.

The Plant-Associated Microbe Gene Ontology Consortium presented a vocabulary resource comprising more than 700 words focusing on microbe-host interactions. The words appear as part of eight papers is a special supplement to BMC Microbiology.

Imperial College London and its spinout DNA Electronics have created a prototype for the so-called SNP Dr., which is being developed under a £1.2 million project that also includes Pfizer.

The company plans this year to add new markers to its HERmark breast cancer test, and will try to ink more collaborations with drug makers in order to embed its VeraTag assays in cancer drug trials.

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The New York Times Magazine examines gender discrimination at the Salk Institute.

Science reports that MD Anderson Cancer Center has dismissed three researchers over foreign tie concerns.

A second death in gene therapy trial for type 1 spinal muscular atrophy is under investigation, according to Reuters.

In PLOS this week: antibiotic resistance patterns in Escherichia coli, a dozen genetic loci tied to varicose vein risk, and more.