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All three methods build on the use of methyltransferases to mark accessible regions of the genome, using nanopore sequencing to detect the modifications.
Nuclease-deficient mouse models revealed a stepwise process for the transformation of intact DNA molecules into circulating cell-free fragments.
Australian researchers have developed a predictive lifespan clock based on CpG density at 42 different promoter sites.
The UK-based company's revenues are generated exclusively from epigenetic biomarker research and development alliances with commercial and academic partners.
Researchers compared single-cell transcriptomic and epigenetic profiles of healthy blood cells and leukemia samples to find a role for RUNX1 in disease.
A group led by Mount Sinai researchers said this methyltransferase, which is involved in sporulation, could be targeted to fight infections.
The Diagenode services will utilize Bio-Rad's ddSEQ Single-Cell Isolator to encapsulate thousands of cell nuclei or whole cells into nanoliter-sized droplets.
The buccal epithelial cell-based epigenetic clock corresponded with age in those under 20, but skewed slightly higher in a small subset of children with autism spectrum disorder.
A new sequencing-based method developed by Duke University's Kate Meyer is one of several that can detect RNA methylation without the use of antibodies.
Researchers identified variants in the germline that appear to influence DNA methylation levels in prostate cancer tumors or in precancerous tissues.
The firm is part of a research consortium that is led by Mount Sinai and includes Fluidigm to develop a device to detect epigenetic signatures of WMD exposure.
Denisovans, an extinct group of humans, likely shared some anatomical traits with Neanderthals and humans but also had some that were specific to them.
Machine learning and DNA methylation analyses helped distinguish between primary lung tumors and lung tumors stemming from head and neck cancer metastasis.
Investigators identified dozens of Alzheimer's-related epigenetic signatures based on cytosine methylation and other profiles in Alzheimer's-related cell lines and patient samples.
Fluidigm will develop a microfluidic device for single-cell measurement of epigenetic changes under a broader $27.8 million DARPA-funded project.
The grant was awarded as part of DARPA's Epigenetic Characterization and Observation program, which aims to develop new approaches to epigenetic analysis.
A collaboration with ATAC-seq experts at the Broad Institute suggests the Bio-Rad assay can analyze tens of thousands of cells per experiment.
The new grant will be used to conduct whole-exome sequencing on 1,000 children participating in an autism spectrum disorder study for the purposes of biomarker development.
The researchers are aiming to find molecular signatures in blood that identify previous exposures to materials associated with weapons of mass destruction.
The firm is in the midst of a clinical trial called NOVA to compare its circulating-tumor DNA-based Colvera test to DiaSorin's carcinoembryonic antigen assay.
Reuters reports that Germany is seeking to sequence 5 percent of patient samples that test positive for SARS-CoV-2.
23andMe and Medscape say primary care physicians are increasingly more comfortable with discussing direct-to-consumer genetic testing results.
The publisher of the Science family of journals will allow some authors to place peer-reviewed versions of their papers into publicly accessible repositories.
In Science this week: analysis of genome-wide association studies of chronic kidney disease, and more.