At the Plant and Animal Genomes conference, a Cold Spring Harbor Lab researcher provided information on an upcoming study of maize regulatory elements.
Researchers at UCSF used CRISPR interference to knockdown lncRNA transcripts, then assayed for cell growth to get the final list of almost 500.
The researchers used genome and epigenomic data to identify distinct subtypes of a lethal pediatric cancer, as well as potential drug candidates.
Dartmouth researchers characterized 5-methylcytosine and 5-hydroxymethylcytosine marks in more than two dozen glioblastoma samples.
The researchers found that 80 percent of pediatric posterior fossa ependymomas have decreased levels of H3K27me3 histone modifications.
The goal of the Texas team is to identify methylation signatures that can help with prognosis and be used to develop noninvasive tests to monitor disease progression.
Researchers have released new tools for analyzing epigenomic data as part of the International Human Epigenome Consortium.
The company has also expanded its current Veracity NIPT to sex chromosomal aneuplodies and twin pregnancies, and plans to offer microdeletion testing next year.
Babraham Institute researchers used promoter capture Hi-C to determine the interactomes of 31,000 promoters in blood cells.
Using two guide RNAs to excise chunks of the genome, an international team identified lncRNAs essential and inhibitory to human cancer cell line proliferation.
The DNA methylation age concept, developed by UCLA geneticist Steve Horvath, uses 353 markers obtained from Illumina methylation arrays.
Scientists led by the Scripps Research Institute's Benjamin Cravatt have developed probes and a mass spec method to find methyltransferases in human cells.
The funding, which is part of the NIH’s Common Fund, supports high-impact biomedical research that produces new insights into genomics and human disease.
Two Broad Institute teams, led by Eric Lander and Feng Zhang, respectively, have published new papers today in Science on new uses for lenti-CRISPR screens.
Researchers analyzed cytosine methylation profiles for 34 angiosperm plants, considering methylation levels and distribution across flowering plant families.
The authors used a sequencing technique to identify secondary DNA structures, showing that they are more prevalent in cancer genes and may make good drug targets.
The partners are working together to advance research into the role of epigenetics in respiratory diseases such as asthma and COPD.
Through their combined genetic and epigenetic study of schizophrenia, the researchers have generated a list of genes affected by risk factors for the disease.
The group is continuing to validate the method for other epigenetic modifications and is looking to partner for commercial development.
The agency will fund research into the mechanisms by which social experiences affect gene function to influence disease in health disparity populations.
While gene therapies may have high price tags, they could be cheaper than the cost of managing disease, according to MIT's Technology Review.
Researchers are looking for markers that indicate which cancer patients may respond to immunotherapies, the Associated Press writes.
In Nature this week: paternal age associated with de novo mutations in children, and more.
Nature News writes that researchers are still wrangling over the role of the p-value.