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Researchers combined genome-wide association and transcriptome study data to uncover cell types affected by complex brain disorders, including Parkinson's disease.
These cells in the nose may serve as the virus entry point, according to an analysis of a single-cell RNA sequencing dataset spanning multiple tissue types.
The researchers studied the admixture of humans and Neanderthals using 14 million archaic chromosome fragments detected in whole genomes from 27,566 Icelanders.
The researchers identified specific macrophage and conventional dendritic cell subsets as key mediators of cellular crosstalk in the tumor microenvironment.
Tumors from patients who underwent full surgical resection had distinct molecular profiles from those treated with neoadjuvant chemotherapy.
The researchers said a functional investigation of the virus' unknown transcripts and RNA modifications will elucidate its life cycle and pathogenicity.
Ann Arbor, Michigan-based Celsee offers instruments and consumables for isolating, detecting, and analyzing single cells.
The data identified common variants that alter gene expression constantly across development, or predominantly during the prenatal or postnatal stages.
The researchers applied their approach to study the heterogeneity of immune cells and adapted a visualization tool to analyze the data.
The company said its product and services revenues were about $24.5 million for the quarter, 15 percent higher than the same period last year.
The researchers identified rare germline loss-of-function variants across the ELP1 gene in 14 percent of pediatric patients in a medulloblastoma subgroup.
A new study showed that relying on minimal phenotyping could impede researchers' ability to identify genetic pathways specific to major depressive disorder.
The researchers, from various institutions in China, said they hope their data will contribute to the completion of the international Human Cell Atlas project.
Researchers found that small-molecule inhibitors targeting oncogenic signal transduction or epigenetic regulation can alter specific 3D interactions in leukemia.
The screen, which multiplexes Cas9 and Cas12a, could be used for functional analysis of large genomic regions in mammalian cells, the researchers said.
The analysis of a hippocampus cell layer uncovered genetic loci associated with schizophrenia risk, including two that may represent drug targets.
The clinics see patients whose overall health may benefit from learning about their genetic predisposition for certain medical conditions.
Multi-omics approaches can give insight into the gut microbiome and more, but there are still challenges to address, speakers at the ABRF meeting said.
The initiative is aiming to solve some of the existing problems in genomics research and build a resource that takes a step beyond gnomAD.
The company plans to offer four new products by the end of the year, including four targeted transcriptomic panels and IHC compatibility for Visium.
According to Science, the US National Academy of Sciences is poised to eject two members accused of sexual harassment.
A UK study on mixing SARS-CoV-2 vaccines is expanding to include vaccines developed by additional companies, according to the Guardian.
In Nucleic Acids Research this week: machine learning approach to detect DNA-bound proteins, CRISPR-based method for activating specific gene targets, and more.
The FDA and CDC call for a pause in administering Johnson & Johnson's SARS-CoV-2 vaccine while reports of rare blood clots are looked into, reports the Wall Street Journal.