Stanford University's Michael Snyder found that methylome shifts preceded spikes in his blood glucose levels, suggesting profiling could detect disease.
Using a mouse model of immunotherapy resistant disease, the researchers found that this program could be targeted by an inhibitor to improve response.
Researchers have uncovered circadian phase gene expression biomarkers that can estimate phase to within three hours.
Screening of disease-linked cell types might bolster drug discovery efforts in schizophrenia, according to a proof-of-concept study.
The researchers found that genes whose transcription in response to an immune challenge diverged across species also varied between single cells.
The team's Pro-Code system enabled simultaneous high-dimensional protein-level phenotyping of hundreds of genes with single-cell resolution.
About a third of the basal-like subgroup harbored IDH2 R172 hotspot mutations, which have also been found in other cancer types.
Using a microfluidics-based single-cell isoform RNA-seq approach, researchers clustered cerebellar cells and saw isoforms with cell type-specific expression.
The researchers used the platform, named CRISPR-GO, to study how spatial organization of the genome in the nucleus governs cellular function.
Fluidigm will provide DNA Software's CopyCount-CNV software for use with its Biomark HD system for copy number variation analysis.
This Tabula Muris could enable discovery of new cell types, detection of novel gene expression in known cells, and comparison of cell types across organs.
Cells that express genes linked to greater proliferation potential are more likely to downregulate the HIV provirus, according to a new study.
The firm's suite of tests, based on its Factorial system, produce cellular signatures offering clues to a compound's toxicity and the types of pathways it perturbs.
For the first time, researchers used mitochondrially targeted zinc-finger nucleases to induce specific elimination of mutant mtDNA across the heart.
Results from a small study suggest that blood biomarkers could be used to test for acute sleep loss and related problems such as drowsy driving.
The company is marketing the panel, which runs on NanoString Technologies' nCounter System, to chemical and cosmetics firms as a replacement for animal models.
The researchers were able to measure the fitness effects of thousands of natural genetic variants in yeast at single-base resolution.
Researchers developed a k-mer-based classification scheme to assay lncRNA function, identifying cis-repressive lncRNAs with k-mer features resembling Xist.
The RNA-seq data, for nearly 40,000 cells from the developing mouse brain, can be explored through an interactive online interface called Cell Seek.
The predictor, based on 15 pairwise relations between immune checkpoint genes, identified almost all true responders and misclassified fewer than half of non-responders.
Bloomberg reports that the DNA-for-cash deal reported in Kentucky might be a more widespread scam.
St. Jude Children's Research Hospital scientists have treated infants with X-linked severe combined immunodeficiency using gene therapy in an early phase study.
St. Louis Public Radio reports that some African Americans are turning to DNA ancestry testing to help guide genealogical searches.
In Nature this week: a genomic analysis of the snailfish Pseudoliparis swirei, ancient DNA analysis gives insight into the introduction of farming to England, and more.