The predictor, based on 15 pairwise relations between immune checkpoint genes, identified almost all true responders and misclassified fewer than half of non-responders.
A study found that cis-regulatory variation modifies the penetrance of coding variants, and that variants' regulatory haplotype configuration affects disease risk.
Led by researchers at the University of Iceland, the study combined deep proteomic, genomic, and phenotypic data from a cohort of more than 5,000 subjects.
While the '3G' study did not establish clinical utility, the researchers said it shows genomic profiling to guide gastric cancer treatment is feasible.
Using the method, the researchers predicted the effects of over 140 million mutations in different tissues and identified mutations possibly associated with increased risk of several immune diseases.
Using Cancer Genome Atlas data, the researchers identified about 1,100 genes in a range of cancer types whose expression is disrupted by structural variants.
The technique features sequencing-by-ligation and error-correction strategies, and was used to simultaneously map more than 1,000 genes in mouse brain tissue.
An international research team uncovered differences in both host and parasite gene expression between uncomplicated and severe malaria cases in The Gambia.
At ASCO, researchers presented on the WINTHER trial, which despite setbacks showed that both DNA and RNA analysis can be used to guide personalized treatment strategies.
The partners will use NanoString's PanCancer panel in NCI-sponsored trials to characterize immune activity and develop potentially predictive gene signatures.
A University of Michigan-led team found that the lncRNA ARLNC1 forms a feedback loop with the androgen receptor to promote progression in prostate cancer.
The genetic risk of schizophrenia is influenced by early-life complications and the placenta differentially expresses these complication-linked genes, a new study says.
Three new studies have used single-cell RNA sequencing methods to follow cell type trajectories over the course of zebrafish and Western claw-toed frog development.
Consulting company McKinsey says diagnostics companies will have to combine genomic data analysis, electronic medical records, effective reimbursement strategies, and regulatory compliance in order to win.
A new report has found that researchers in Africa are still heavily dependent on funding from organizations in the US, Europe, and China, Nature News says.
