Cells that express genes linked to greater proliferation potential are more likely to downregulate the HIV provirus, according to a new study.
The firm's suite of tests, based on its Factorial system, produce cellular signatures offering clues to a compound's toxicity and the types of pathways it perturbs.
For the first time, researchers used mitochondrially targeted zinc-finger nucleases to induce specific elimination of mutant mtDNA across the heart.
Results from a small study suggest that blood biomarkers could be used to test for acute sleep loss and related problems such as drowsy driving.
The company is marketing the panel, which runs on NanoString Technologies' nCounter System, to chemical and cosmetics firms as a replacement for animal models.
The researchers were able to measure the fitness effects of thousands of natural genetic variants in yeast at single-base resolution.
Researchers developed a k-mer-based classification scheme to assay lncRNA function, identifying cis-repressive lncRNAs with k-mer features resembling Xist.
The RNA-seq data, for nearly 40,000 cells from the developing mouse brain, can be explored through an interactive online interface called Cell Seek.
The predictor, based on 15 pairwise relations between immune checkpoint genes, identified almost all true responders and misclassified fewer than half of non-responders.
A study found that cis-regulatory variation modifies the penetrance of coding variants, and that variants' regulatory haplotype configuration affects disease risk.
Led by researchers at the University of Iceland, the study combined deep proteomic, genomic, and phenotypic data from a cohort of more than 5,000 subjects.
While the '3G' study did not establish clinical utility, the researchers said it shows genomic profiling to guide gastric cancer treatment is feasible.
The company hopes to launch its first clinical cancer test within the next year, after spending the last several years conducting validation studies.
Using the method, the researchers predicted the effects of over 140 million mutations in different tissues and identified mutations possibly associated with increased risk of several immune diseases.
Using Cancer Genome Atlas data, the researchers identified about 1,100 genes in a range of cancer types whose expression is disrupted by structural variants.
The technique features sequencing-by-ligation and error-correction strategies, and was used to simultaneously map more than 1,000 genes in mouse brain tissue.
The approach, published this week in Cell Reports, could be used more generally to discover disease genes in other cancer types.
An international research team uncovered differences in both host and parasite gene expression between uncomplicated and severe malaria cases in The Gambia.
The firm has developed a new classifier for bladder cancer and continues to work with pharma companies in the lung cancer space.
A TWAS in 229,000 women led to 48 genes with apparent links to breast cancer, serving as fodder for additional pathway and functional analyses.
An artificial intelligence-based analysis suggests a third group of ancient hominins likely interbred with human ancestors, according to Popular Mechanics.
In Science this week: reduction in bee phylogenetic diversity, and more.
The New York Times Magazine looks into paleogenomics and how it is revising what's know about human history, but also possibly ignoring lessons learned by archaeologists.
The Economist reports on Synthorx's efforts to use expanded DNA bases they generated to develop a new cancer drug.