The firm's suite of tests, based on its Factorial system, produce cellular signatures offering clues to a compound's toxicity and the types of pathways it perturbs.
The company is marketing the panel, which runs on NanoString Technologies' nCounter System, to chemical and cosmetics firms as a replacement for animal models.
Researchers developed a k-mer-based classification scheme to assay lncRNA function, identifying cis-repressive lncRNAs with k-mer features resembling Xist.
The predictor, based on 15 pairwise relations between immune checkpoint genes, identified almost all true responders and misclassified fewer than half of non-responders.
A study found that cis-regulatory variation modifies the penetrance of coding variants, and that variants' regulatory haplotype configuration affects disease risk.
Led by researchers at the University of Iceland, the study combined deep proteomic, genomic, and phenotypic data from a cohort of more than 5,000 subjects.
While the '3G' study did not establish clinical utility, the researchers said it shows genomic profiling to guide gastric cancer treatment is feasible.
Using the method, the researchers predicted the effects of over 140 million mutations in different tissues and identified mutations possibly associated with increased risk of several immune diseases.
Using Cancer Genome Atlas data, the researchers identified about 1,100 genes in a range of cancer types whose expression is disrupted by structural variants.
The technique features sequencing-by-ligation and error-correction strategies, and was used to simultaneously map more than 1,000 genes in mouse brain tissue.
An international research team uncovered differences in both host and parasite gene expression between uncomplicated and severe malaria cases in The Gambia.
An artificial intelligence-based analysis suggests a third group of ancient hominins likely interbred with human ancestors, according to Popular Mechanics.
The New York Times Magazine looks into paleogenomics and how it is revising what's know about human history, but also possibly ignoring lessons learned by archaeologists.
