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Using Genotype-Tissue Expression project samples, researchers put together gene regulatory networks for 29 tissue types, uncovering extensive sex-related regulatory differences.
Study subjects of both sexes who had low germline mutation rates lived nearly five years longer than individuals with high mutation rates.
Christiana Care researchers have identified a unique protospacer adjacent motif site that allows them to knock out the NRF2 gene in tumor cells while leaving normal cells alone.
Investigators identified an inbred individual who appeared to be part of a high-status group buried in lavish tombs during the Neolithic period.
A meta-analysis including 1.4 million people from five ancestral groups identified 318 novel variants associated with type 2 diabetes and related vascular outcomes.
Sequences from 20 Neolithic and Iron Age individuals in sub-Saharan Africahelped retrace regional interactions between forager, pastoralist, and farming groups.
Polygenic risk scores have the potential to impact cancer screening, autoimmune disease testing, and therapeutics development, but more diverse data is needed.
A method called microbiome-derived metabolism screening highlighted drug alterations after exposure to personalized gut microbe collections.
The framework is meant to guide healthcare providers in facilitating prostate cancer genetic testing in a timely and responsible way, the researchers said.
The GWAS of more than 200,000 Japanese individuals across 42 diseases identified 25 novel loci shared between Japanese and European populations.
A team led by UCSF researchers found that no one viral lineage predominates in the region and that travel and social restrictions may stem spread.
Ancient samples from more than a dozen archaeological sites suggests population movement from South America preceded by at least two earlier migration waves.
Most of the scroll fragments analyzed originated from sheep, but two pieces came from cow, suggesting they were imported to the area where they were found.
Ancestry patterns appeared to shift in parts of northern China during the Neolithic and Bronze Age as populations transitioned to farming-focused and pastoralist subsistence strategies.
The ancestor of a bat coronavirus may have obtained a receptor binding motif found among pangolin coronaviruses through a recombination event.
New data shows that the test could eventually be useful in helping younger women avoid chemotherapy in the neoadjuvant setting.
The INFORM study echoed the 2019 interim results from the NCI Pediatric MATCH trial, which found that 24 percent of participants were eligible for targeted treatment.
The researchers also found that COVID-19 patients had a special trigger host immune response in certain pathways, such as interferon gamma signaling.
Investigators explored population dynamics during the shift to farming with new sequence data from more than 100 individuals from present-day France and Germany.
Independent research teams have tackled the genetic history of the Levant, Anatolia, and other parts of the Near East to retrace population movement and mixing since the Bronze Age.
The founder of MeTooSTEM, BethAnn McLaughlin, created a Twitter account purported to be that of an LGBTQ Native American professor at Arizona State University, the New York Times writes.
Novavax reports its candidate SARS-CoV-2 vaccine leads to immune responses, according to the Sydney Morning Herald.
Gene length is associated with lifespan in a comparative genomics study appearing in the Proceedings of the National Academy of Sciences that draws on the whale shark genome.
In Nucleic Acids Research this week: effort to annotate the rat transcriptome, web-based resource to characterize marine microbes, and more.