A University of Pennsylvania-led team found that genetic population structure in Africa is associated with geography, as well as with language and lifestyle.
The MammaSeq assay comprises 79 genes and 1,369 mutations in breast cancer that could be used as potential downstream therapeutic targets.
Researchers from the Genetics Investigation of Anthropometric Traits consortium tied loci in lipid homeostasis and other pathways to differences in waist-to-hip ratio.
Loss-of-function mutations in PADI3, which was previously linked to uncombable hair syndrome, appear to be involved in central centrifugal cicatricial alopecia.
Several of the novel variants the researchers identified are more common among individuals of Japanese ancestry than of European background.
Researchers sequenced 45 individuals from the Caucasus and steppe region between 3,500 and 6,500 years ago, teasing out distinct populations and shared relationships.
As novel findings emerge from these research efforts, the VA is also contemplating how some of these learnings may be communicated to the participants.
Researchers saw variants contributing to both ends of the weight spectrum by analyzing thousands of thin, early-onset obese, and population control individuals.
In a new policy paper, investigators outlined existing challenges to public data sharing and touted the benefits of increasing openness before and after publication.
The project has signed up about 170,000 participants so far, of whom 100,000 are fully enrolled, and plans to enhance recruitment through pop-up clinics.
Cancer Research UK has awarded nearly £60 million in funding to three US investigator-led research initiatives focused on cancer progression and drug response.
The nuclease, which comes from Bacillus hisashii, has gain-of-function mutations that facilitate robust editing in human cell lines and primary human T cells.
One locus appears to be more common among individuals with Native American or East Asian ancestry and suggests there was convergent evolution of skin color among Eurasians.
A number of the genes implicated are also the targets of approved therapeutics or of ones under testing.
Researchers were able to classify 1,244 of 4,585 putatively clinically relevant rare variants genotyped on the UKB microarray as high quality.
Kansas State University's Barbara Valent outlined genomics research underway to combat a fungal pathogen with the potential to seriously compromise wheat production.
Researchers also found that Neanderthals differed from humans more in the regulatory than protein-coding sequences of their genomes.
An international team found 566 variants in 406 loci, 150 of which evidenced pleiotropic association for alcohol and tobacco use.
Results from two GWAS studies suggest that 15-LO inhibitors could be a viable treatment for nasal polyps and chronic rhinosinusitis.
At the Plant and Animal Genome conference, a researchers discussed the prospect of doing pan-genome studies in barley despite the plant's genomic complexity.
Two researchers are calling for education for scientists on defending facts.
Researchers were among those who marched in London this weekend to call for another vote on Brexit.
Duke has agreed to pay $112.5 million to settle a lawsuit regarding its handling of data falsified by biologist Erin Potts-Kant.
In PLOS this week: genetic factors influencing inorganic arsenic metabolism and toxicity, a germline variant in the cell adhesion molecule-coding gene DSCAM, and more.