The team found that base editors that exhibit RNA off-target editing can also self-edit their own transcripts, leading to heterogeneity in their coding sequences.
The team tested the system in living mice with progeria, inserting a normal copy of the LMNA gene into the animals to diminish features of the disease.
The NAM, NAS, and Royal Society have formed a commission to develop a framework on the proper use of genome editing, and convened its first meeting in Washington, DC, this week.
Investigators saw signs that risky TP53 missense mutations may interfere with wild type copies of the tumor suppressor gene in acute myeloid leukemia and other myeloid cancers.
The Economist reports that it is increasingly easier to analyze the metabolites people give off, potentially revealing personal information about them.
