Wellcome Sanger Institute researchers showed that Cas9-induced DNA breaks frequently resolved into deletions extending over many kilobases in the genome.
The Somatic Cell Genome Editing program was established earlier this year to help remove barriers from the adoption of genome editing for treating patients.
In exchange, Editas has the exclusive right to be the first to negotiate for licenses to genome-editing inventions that arise from the sponsored research.
The approach generates a gRNA against a common genetic element called the flippase recognition target, making genome editing faster and scarless in E. coli.
By combining iPSCs, CRISPR gene editing, and transcriptomic approaches, researchers examined the effects of an Alzheimer's disease risk variant on brain cells.
The NMI Natural and Medical Sciences Institute at the university and its affiliate will use the patents to expand their cell-based research service offerings.
By using array-synthesized guide-donor oligonucleotide pairs, the team's gene editing technique allows accurate and detectable phenotyping in yeast cells.
The company — which was cofounded by David Liu, Feng Zhang, and Keith Joung — has licensed base editing technology from Harvard and the Broad Institute.
Researchers used CRISPR-Cas9 screening assays in mouse and human cells to track down point mutations in the PARP1 gene that boost resistance to PARP inhibitor drugs.
The technology behind Mammoth's platform bears a striking resemblance to the CRISPR-based SHERLOCK platform developed by researchers at the Broad Institute.
Stanford University's Eilon Sharon used CRISPeY to conduct a genome-wide precise editing study to study the fitness consequences of variants found in different yeast strains.
Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.
