Two new studies identified extensive RNA scaffolds underlying the increased editing efficiency of these nucleases.
Promega said it will combine the CRISPR technology with its own products that are designed for knock-in of genetic reporters into cells or cell lines.
The partners are planning to integrate the technology into Horizon's research tools and services and to develop it for applications in cell therapeutics.
The nuclease, which comes from Bacillus hisashii, has gain-of-function mutations that facilitate robust editing in human cell lines and primary human T cells.
The protease-activated Cas9 enzymes could reduce off-target effects and could be used to sense pathogens and trigger an immune response.
GreenLight Biosciences is using a proprietary cell-free RNA production technology to develop RNA-based products for the agricultural market.
The partners will work to find novel proteins, including DNA endonucleases, to develop new gene editing therapies for cystic fibrosis and other diseases.
Ohio State University researchers found that a phosphorothioate-modified DNA-crRNA duplex completely blocked the function of Cas12a.
The firm is developing and beta-testing a line of guide RNA libraries to support CRISPR-based targeted capture and sequencing approaches.
The company, which had raised $55.5 million in February, said its investors have agreed to contribute an additional $30 million.
Evogene and Tropical Melhoramento & Genetica aim to develop non-genetically-modified nematode-resistant soybeans using CRISPR genome editing.
A systematic analysis of CRISPR genome editing at nearly 1,500 target sites has yielded some patterns that could make genome editing more precise.
The pharma and biotech company said it plans to use the genome editing technology in its bioproduction products and services and in stem cells for research.
The method, called negative enrichment, protects DNA regions of interest prior to degrading the surrounding DNA, making the target fragments easier to read.
As they dig into the data on He Jiankui's genome editing experiment, CRISPR researchers say the work he did raises many scientific questions.
The 9p21.3 locus influences the expression of other genes, and affects cell adhesion and contractile force of vascular smooth muscle cells.
Even as He Jiankui expressed pride in the work he had done to alter the CCR5 genes of twin embryos, researchers and ethicists decried him as misguided.
The researchers studied edits generated by more than 40,000 gRNAs and gathered data for more than 109 mutational outcomes to create the software.
Eurofins will distribute Synthego's sgRNA products to its customers in 44 countries.
The investigators showed that template-free Cas9 editing is capable of repair to a predicted genotype, allowing for correction of disease-associated mutations.
A bill passed by a US House of Representatives appropriations subcommittee would give scientific agencies including the National Science Foundation boosts in funding.
University of Idaho researchers model the scientific discovery process to examine the link between reproducibility and scientific truth.
Relocating USDA agencies outside of Washington, DC, may make them less effective, critics of the move tell NPR.
In PLOS this week: genes that help Borrelia burgdorferi survive in ticks, CiliaCarta collection of about 1,000 suspected cilia genes, and more.