The method combines stable isotope dimethyl labeling with DiLeu isobaric tagging and allows multiplexing of up to 24 samples in a single mass spec experiment.
The ability to effectively use FFPE tissue opens up a large number of clinical samples for analysis, many with quality data on patient demographics, treatment, and outcomes.
The company said the funds will be used to expand its management team and complete commercialization of its mass spec multinozzle emitter array technology.
The company reported revenues of $443.7 million and organic growth of 3 percent, driven in large part by strength in its scientific instruments business.
Waters said the acquisition is part of a strategy to develop simpler, more streamlined mass spec workflows that will be accessible to non-expert users.
The study, which coupled FAIMS to an Orbitrap mass spec, indicates the technology could streamline proteomics experiments without sacrificing depth of analysis.
Dian selected the MassArray system as its platform of choice for molecular genetic testing and will commercialize it and Agena's DNA applications and products.
The researchers identified 669 and quantified 332 proteins in single cells, making this one of the most comprehensive mass spec-based experiments of its kind.
The reagents are intended for use in a recently developed workflow designed to address the precursor interference issue that has troubled the labeling method.
With the release of its Q Exactive UHMR system and a new $130 million NIH program, the company sees opportunity to expand use of its cryo-EM and mass spec techs.
Major releases were relatively sparse at ASMS as many vendors focused instead on the development of applications and workflows for their existing platforms.
The study combined large-scale protein post-translational modification datasets with protein-protein interaction data to profile cell signaling in lung cancer.
Developed in the lab of Max Planck's Matthias Mann, the approach adjusts the sampling of ions during the initial scan to boost assay sensitivity and reproducibility.
In PLOS this week: similar variants seen in bullbogs, people with Robinow syndrome; ApoE genotypes in African-American, Puerto Rican populations; and more.
