A number of the variants uncovered by an international research team appear to "tune" which hematopoietic cell lineage is produced.
Together with gene expression results from affected tissue, the findings suggest that drugs such as JAK inhibitors may be effective for the treatment of FFA.
A genome-wide association study involving more than 12,300 carpal tunnel syndrome patients and controls from the UK Biobank led to 16 genetic loci.
University of Bristol researchers unearthed variants that implicate the immune system in the risk of developing mouth ulcers.
The findings implicated immune response, lipid metabolism, tau binding proteins, and amyloid precursor protein metabolism pathways in disease risk.
Genome- and exome-wide association analysis on inflammatory bowel disease patients with or without thiopurine-induced myelosuppression revealed new and known risk genes.
The two genome-wide association studies of chronic obstructive pulmonary disease uncovered numerous novel risk variants, including ones in genes involved in ciliogenesis and lung development.
Using data for more than a million individuals with or without insomnia, two independent research teams tracked down associated risk loci and explored their functional effects.
Researchers used a genome-wide association study to identify seven loci associated with ASD and other conditions, along with five loci linked to ASD alone.
These loci include a known asthma locus at 17q12-q21, but also loci at 8p23 and 8q24 that could be specific to asthma risk among individuals of African ancestry.
Investigators calculated that the new assay, which includes 67 SNPs, could offer a 50 percent improvement over previous methods if used in newborn screening.
The revelation that Family Tree DNA has been working with law enforcement has some worried about a negative impact on the industry.
The findings underscored links between depression and other conditions and suggested a number of potential new targets for treatment with existing drugs.
Several of the novel variants the researchers identified are more common among individuals of Japanese ancestry than of European background.
Polygenic risk scores for depression, bipolar disorder, and schizophrenia are associated with depression in a general population cohort.
The company said that the revenue increase has been driven by growth in its sequencing business, particularly as genomics moves into the clinic.
Using UK Biobank and 23andMe data, researchers found 352 loci influencing sleep time preferences, including sites near brain- and retina-expressed genes.
Researchers saw variants contributing to both ends of the weight spectrum by analyzing thousands of thin, early-onset obese, and population control individuals.
Decode Genetics researchers used the map to examine how often and where recombination events and de novo mutations occur in the human genome.
At the Precision Medicine World Conference, researchers from Sanford Health, Providence Health, and Israel's Maccabi discussed their genomics programs.
New research shows that scientists need to do a better job of including a wider diversity of African genomes in their analyses, STAT says.
A new paper in Science shows that men are still winning a large majority of the most sought-after NIH grants.
Nature Research and the Estée Lauder Companies are awarding efforts to encourage girls to pursue careers in the STEM fields.
In Science this week: beneficial genetic variants inherited from archaic Neanderthal and Denisovan hominins, and more.