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Vitra Bioscience and Meso Scale Technologies Among Recent US Patent Winners


Virtual Arrays (Vitra Bioscience) has been awarded US Patent No. 6,977,152, "Biological assays using coded RNA reporters."

Inventors listed on the patent are Gordon Foulkes and Oren Beske.

According to its abstract, the patent protects systems for multiplexed analysis of gene expression using coded RNA reporters. The coded RNA reporters are expressed from a library of reporter genes, with each reporter gene directing expression of a distinguishable coded RNA reporter. Each RNA reporter thus reports activity of a corresponding reporter gene. The distinguishable reporter RNA species allow otherwise similar reporter genes to be functionally linked to different effectors within a cell reporter library. Multiplexed analysis of reporter gene activity is carried out by measuring the level of each RNA reporter within the cell reporter library, thus providing an ability to analyze the effect of a biological modulator on many effectors, the abstract states.

Streck Laboratories has been awarded US Patent No. 6,977,156, "Flow cytometry reagent and system."

Inventors listed on the patent are Wayne Ryan and Paula Turpen.

According to its abstract, the patent protects an improved reagent system for preparation of cells for flow cytometry having a physiologically compatible salt solution composition including a lysing agent, an agent for minimizing white blood cell lysis, and optionally a preservative.

Astellas Pharma has been awarded US Patent No. 6,977,157, "Clock gene promoter."

Inventors listed on the patent are Tomohiro Takasugi, Wenbin Chen, and Seiichi Hashimoto.

According to its abstract, the patent protects a Period2 gene promoter; a construct containing the promoter and a reporter gene; a cell containing the construct; a transgenic animal harboring the construct; and a method for screening a substance which controls expression or oscillatory expression of a biological clock gene. The screening method uses the above cell, a suprachiasmatic nucleus section or peripheral tissue of the above transgenic animal, or the above transgenic animal, the abstract states.

Mitsubishi Chemical has been awarded US Patent No. 6,977,160, "Sensor protein and use thereof."

Inventors listed on the patent are Hiroshi Yanagawa, Nobuhide Doi, and Naoto Nemoto.

According to its abstract, the patent protects the use of a sensor protein that has a molecular recognizing ability in which it scarcely undergoes any structural change by the binding of a target substance. The patent describes a sensor protein comprising an insert-type fusion protein composed of a reporter protein and a binding protein, wherein said binding protein is inserted into the amino acid sequence of said reporter protein, the abstract states.

Innovation and Development Corporation has been awarded US Patent No. 6,977,172, "Method and apparatus for targeting localized electroporation."

Inventors listed on the patent are Robert Burke, Ross Atkins, and Diana Wang.

According to its abstract, the patent protects an apparatus and a method of effecting localized electroporation in a relatively small target area and for introducing foreign matter into cellular material in which the target area is located. The cellular material may be in vitro, in ovo, or in vivo, the abstract states.

Meso Scale Technologies has been awarded US Patent No. 6,977,722, "Assay plates, reader systems, and methods for luminescence test measurements."

Inventors listed on the patent are Jacob Wohlstadter, Eli Glezer, James Wilbur, George Sigal, Kent Johnson, Charles Clinton, Alan Kishbaugh, Bandele Jeffrey-Coker, Jeff Debad, and Alan Fischer.

According to its abstract, the patent protects a method for luminescence test measurements that are conducted using an assay module having integrated electrodes with a reader apparatus. The apparatus is adapted to receive assay modules, induce luminescence (preferably electrode-induced luminescence) in the wells or assay regions of the modules, and measure the induced luminescence, the abstract states.

The Scan

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A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.