Vanderbilt Team Uses Enzymatic, Cell-Based Assays to Find Phospholipase D Inhibitors | GenomeWeb

Investigators at Vanderbilt University Medical Center have developed what they claim to be the first isoform-selective phospholipase D inhibitors, a new class of potential antimetastatic agents.

The researchers used a screening approach that evaluates the effects of small molecules in both in vitro enzymatic assays and cell-based assays to compare the PLD-inhibiting activities of existing compounds as well as a library of new compounds generated in the laboratory, a Vanderbilt official told CBA News this week.

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