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UW-Madison, EMD Biosciences, Compugen

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New UW-Madison Research Program Awards $3M in Grants; Projects Include hESC Production, Cell-Based Drug Discovery
 
The Wisconsin Institutes for Discovery at the University of Wisconsin-Madison this week announced the results of a campus-wide competition for around $3 million in “Discovery Seed Grants.”
 
The eight winning proposals included research on methods for large-scale production of human embryonic stem cells; new tools for zebrafish-based anti-inflammatory drug discovery; and a system for identifying compounds that can regulate cellular ligand-gated ion channels.
 
The Wisconsin Institutes for Discovery is funded by gifts from UW-Madison alumni John and Tashia Morgridge, the Wisconsin Alumni Research Foundation, and the state of Wisconsin. The WID building is slated for completion in 2010.
 
UW-Madison said that the seed grants will represent WID’s first research activities.
 

 
EMD Biosciences to Market siRNA, DNA Transfection Reagents from DNT
 
EMD Biosciences, part of Merck KGaA’s Performance and Life Science Chemicals division, has signed an exclusive license and supply agreement with Dendritic Nanotechnologies for siRNA and DNA transfection reagents, the companies said this week.
 
Under the terms of the agreement, DNT, a US subsidiary of Australian firm Starpharma, will supply EMD Biosciences with its Priofect transfection reagents. EMD will market the reagents through its Novagen product line.
 
DNT retains full rights to all in vivo aspects of transfecting nucleic acids with the Priostar technology. Additional terms of the agreement, which includes royalties and milestone payments, were not disclosed.
 
According to DNT, PrioFect transfection reagents offer nanometer-size control, which will enable EMD to offer siRNA transfection reagents with sizes optimized for individual cell lines.
 

 
Compugen Finds Eight Novel GPCR Peptide Ligands With New Discovery Engine
 
Compugen said this week that it has discovered eight novel peptides that activate G protein-coupled receptors using a new GPCR ligand discovery engine.
 
The discovery engine uses proprietary machine-learning algorithms to analyze the predictive peptidome. Using the discovery engine, Compugen researchers discovered hundreds of peptides likely to activate GPCRs, of which 33 novel peptides were synthesized and screened in a functional assay against a panel of 152 GPCRs, Compugen said in a statement.
 
Eight were shown to activate six different GPCRs in a concentration-dependent manner. Some of the GPCRs have no known endogenous ligands. The receptors for which novel ligands have been discovered include the MAS 1 and MAS-related GPCRs, MRGX 1 and MRGX 2, FPRL 1, and the two Relaxin family receptors, RXFP 1 and RXFP 2.

The Scan

Interfering With Invasive Mussels

The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels.

Participation Analysis

A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports.

Right Whales' Decline

A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC.

Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map

In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.