University of Pennsylvania School of Medicine scientists have developed a high-throughput functional cell-based screen using bioluminescence imaging to identify small molecules that modulate p53 transcriptional activity or p53-related proteins in cancer cells, and exhibit anti-cancer activity in human colon cancer xenografts.

The study underscores the importance of p53-related pathways and downstream molecules as potential drug targets, and could help establish bioluminescent cell-based assays as an effective way to screen modulators of such targets.

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Science speaks with the University of Michigan's Jedidiah Carlson, who has tracked population genetic discussions at white nationalist sites.

Gene therapies could qualify for a faster US Food and Drug Administration approval process, according to Stat News.

NPR reports that the US House of Representatives has passed a bill to enable terminally ill patients access to experimental drugs.

In Genome Research this week: inversion variants mapped in human, non-human primate genomes; transcriptome profiling of maize, sorghum; and more.