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University of Florida Research Foundation, University of Sydney, Dade Behring Marburg, IRM, and Beckman Coulter Awarded US Patents

The University of Florida Research Foundation in Gainesville and the University of Sydney, Australia, have been awarded US Patent 7,230,080, “Fluorescent and colored proteins, and polynucleotides that encode these proteins.”
Inventors listed on the patent are Mikhail Matz, Naila Alieva, Karen Ann Konzen, Steven Field, and Anya Salih.
According to its abstract, the patent provides “new fluorescent and/or colored proteins, and polynucleotide sequences that encode these proteins. The subject invention further provides materials and methods useful for expressing these detectable proteins in biological systems.”

Dade Behring Marburg of Marburg, Germany, has been awarded US Patent 7,229,842, “Metal chelate containing compositions for use in chemiluminescent assays.”
The inventors listed on the patent are Sharat Singh and Edwin Ullman.
According to its abstract, the patent discloses “Compositions comprising (a), a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium osmium, and ruthenium in at least a hexacoordinated state; and (b), a compound having a double bond substituted with two aryl groups, an oxygen atom, and an atom selected from the group consisting of oxygen, sulfur, and nitrogen wherein one of the aryl groups is electron donating with respect to the other. Such composition is preferably incorporated in a latex particulate material.” The abstract adds that, “Methods and kits are also disclosed for determining an analyte in a medium suspected of containing the analyte. The methods and kits employ as one component a composition as described above.”

IRM of Hamilton, Bermuda, has been awarded US Patent 7,229,768, “Universal G-protein coupled receptor reporter constructs.”
The inventors listed on the patent are Yinghe Hu and Cecilia Jiang.
The patent provides universal G protein-coupled receptor reporter constructs, according to its abstract, which “comprise a serum response element, a cAMP response element, and a multiple response element. These reporter constructs are able to detect activities of all GPCRs examined.” Also provided are host cells harboring a universal GPCR reporter construct of the invention, in addition to assays for detecting modulators of GPCRs using the host cells.

Beckman Coulter has been awarded US Patent 7,229,763, “Assay system using labeled oligonucleotides.”
Inventors listed on the patent are Parameswara Reddy, Daniel Keys, and Firdous Farooqui.
The patent provides a system for assays that comprises a solid support, a plurality of capture oligonucleotides immobilized onto the solid support, and complementary oligonucleotides attached to capture ligands, according to its abstract. “A detectable label can be directly attached to the capture oligonucleotides or the complementary oligonucleotides. The labeled oligonucleotides can be detected and used to determine the quality of the assay. A labeled detector ligand corresponding to a target ligand can also be independently detected apart from the labeled oligonucleotide,” the abstract states.

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