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University of California Wins US Patent for Cell-Based Screening Method


The University of California has been awarded US Patent No. 6,911,314, "Screening for drugs that affect TNF receptor releasing enzyme."

Inventors listed on the patent are Tetsuya Gatanaga and Gale Granger.

According to its abstract, the patent protects a procedure by which the biological effects of the cytokine TNF are mediated by binding to receptors on the surface of cells. The patent describes new proteins and polynucleotides that promote enzymatic cleavage and release of TNF receptors, the abstract states. Also protected are methods for identifying additional compounds that influence TNF receptor shedding. As the active ingredient in a pharmaceutical composition, the products of described either increase or decrease TNF signal transduction, thereby alleviating the pathology of disease, the abstract states.

The Scan

CDC Calls Delta "Variant of Concern"

CNN reports the US Centers for Disease Control and Prevention now considers the Delta variant of SARS-CoV-2 to be a "variant of concern."

From FDA to Venture Capital

Former FDA Commissioner Stephen Hahn is taking a position at a venture capital firm, leading some ethicists to raise eyebrows, according to the Washington Post.

Consent Questions

Nature News writes that there are questions whether informed consent was obtained for some submissions to a database of Y-chromosome profiles.

Cell Studies on Multimodal Single-Cell Analysis, Coronaviruses in Bats, Urban Microbiomes

In Cell this week: approach to analyze multimodal single-cell genomic data, analysis of bat coronaviruses, and more.