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UCal and Evotec Win Recent Cell Based Assay-Related Patents

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The University of California has been awarded US Patent No. 6,927,049, "Cell viability detection using electrical measurements."

Inventors listed on the patent are Boris Rubinsky and Yong Huang.

According to its abstract, the patent protects a method of determining information about cell viability and other characteristics relating to cell membrane permeability. The method involves determining the effect of a cell on current flow and relating that effect to a known standard, which may be a known healthy cell, and thereby deducing the viability of the cell being tested, the abstract states. The cells being tested can be subjected to different environmental conditions such as surrounding chemicals, temperature, pH, and pressure to determine the effects of such conditions on cell viability and/or cell permeability. The cell being tested can be in a cell suspension, grown on substrate, in tissue in vitro, or in tissue in vivo. The method provides substantially instantaneous results and need not include the use of dyes or other markers, the abstract states.


Evotec has been awarded US Patent No. 6,927,401, "Method of characterizing fluorescent molecules or other particles using generating functions."

Kaupo Palo is the lone inventor listed on the patent.

According to its abstract, the patent protects a method for characterizing fluorescent molecules or other particles in samples comprising the steps of (a) monitoring fluctuating intensity of fluorescence emitted by the molecules or other particles in at least one measurement volume of a non-uniform spatial brightness profile by measuring numbers of photon counts in primary time intervals by a single or more photon detectors; (b) determining at least one distribution of numbers of photon counts from the measured numbers of photon counts; and (c) determining physical quantities characteristic to said particles by fitting the distribution of numbers of photon counts, wherein the fitting procedure involves calculation of a theoretical distribution function of the number of photon counts through its generating function.

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