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Trophos and Rosetta Inpharmatics are Among Recent US Patent Awardees

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Trophos has been awarded US Patent No. 6,949,354, "Methods for screening compounds active on neurons."

Inventors listed on the patent are Pascal Villa, Michel Delaage, Toni Williamson, and Christopher Henderson.

According to its abstract, the patent protects compositions and methods for screening and/or identifying compounds exhibiting biological activity on neurons. The patent also protects a method for the isolation and culture of neurons, methods of inducing pathological conditions to said isolated neurons, as well as kits for implementing said methods, the abstract states. The invention can be used in experimental research, drug discovery, drug development, and the like. More particularly, the invention can be used to identify, characterize, and/or improve compounds which are active on neurons and can be used for treating disorders of the nervous system.


Winston Ho has been awarded US Patent No. 6,949,377, "Chemiluminescence-based microfluidic biochip."

Ho is an employee of Maxwell Sensors, and is the lone inventor.

According to its abstract, the patent protects methods for luminescence detection, to move microfluid, and control multiple-step biochemical reactions in a closed confined microfluidic biochip platform. More particularly, the patent protects a self-contained disposable biochip with patterned microchannels and compartments having storage means for storing a plurality of samples, reagents, and luminescent substrates, the abstract states. At least one external microactuator in the biochip system produces positive pressure and automates multiple-step reactions in microfluidic platforms for clinical chemistry, cell biology, immunoassay, and nucleic acid analysis. The method comprises the steps of transferring sequentially at least one of samples, reagents, and then luminescent substrate from compartments through microchannels to reaction sites. The luminescent substrates react with probes to form a probe complex resulting in luminescence, which is detected by an optical detector, the abstract states.


Rosetta Inpharmatics has been awarded US Patent No. 6,950,752, "Methods for removing artifact from biological profiles."

Inventors listed on the patent are Stephen Friend, Roland Stoughton, and Yudong He.

According to its abstract, the patent protects methods for removing unwanted response components (i.e., "artifacts") from a measured biological profile comprising measurements of a plurality of cellular constituents of a cell or organism in response to a perturbation. The methods involve subtracting from the measured biological profile one or more artifact patterns, each of which comprises measurements of changes in cellular constituents as a result of deviation of one or more experimental variables, such as cell culture density and temperature, hybridization temperature, as well as concentrations of total RNA and/or hybridization reagents, from desired values, the abstract states.

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