Researchers at the University of Toronto have developed a cell-based yeast-phenotypic assay that, when combined with a large-scale inhibitor screen, identified small molecule inhibitors that suppress the toxicity caused by the heterologous expression of selected Pseudomonas aeruginosa open-reading frames.
The research also enabled the investigators to identify what they said is the first small molecule inhibitor of Exoenzyme S, or ExoS, a toxin that is involved in Type III secretion.  

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.