Toronto Team’s Cell-Based Yeast Assay Identifies Pseudomonas Toxin Inhibitor | GenomeWeb
Researchers at the University of Toronto have developed a cell-based yeast-phenotypic assay that, when combined with a large-scale inhibitor screen, identified small molecule inhibitors that suppress the toxicity caused by the heterologous expression of selected Pseudomonas aeruginosa open-reading frames.
The research also enabled the investigators to identify what they said is the first small molecule inhibitor of Exoenzyme S, or ExoS, a toxin that is involved in Type III secretion.  

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