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Technion Research & Development Foundation, HemoGenix, and CellStat Technologies Awarded US Patents

The Technion Research & Development Foundation has been awarded US Patent 7,354,763, “Generating vascular smooth muscle cells in vitro from ES cells.”
Invetors listed on the patent are Sharon Gerecht-Nir and Joseph Itskovitz-Eldor.
The patent provides a simplified and inexpensive method for the in vitro identification, isolation, and culture of human vasculogenic progenitor cells, the abstract said. The method and the progenitor cells described can be used for in vitro vascular engineering, treatment of congenital and acquired vascular and hematological abnormalities, for the evaluation and development of drugs affecting vasculo- and angiogenic processes, and for further investigation into tissue differentiation and development.

HemoGenix has been awarded US Patent 7,354,730, “High-throughput assay of hematopoietic stem and progenitor cell proliferation.”
The inventor listed on the patent is Ivan Rich.
According to the abstract, the patent describes kits that provide reagent mixes and instructions for their use in performing high-throughput assays to determine the proliferative status of isolated target cell populations. The methods measure the luminescent output derived from the intracellular ATP content of incubated target cells, and correlate the luminescence with the proliferative status of the cells.
The present invention also describes kits that provide reagent mixes and instructions for their use in running high-throughput assays to screen compounds that may modulate the proliferative status of a target cell population, its abstract said. The kits may be used for determining the proliferative status of any isolated cell line or type.

CellStat Technologies has been awarded US Patent 7,354,704, “High throughout screening method and apparatus.”
The inventors listed on the patent are Patricia Malin, Kenneth Wada, and Peter Dehlinger.
The patent discusses a high-throughput screening method and apparatus arm. The method includes placing cells on a substrate with discrete microwells, at a well-density of greater than about 100/cm2, with the number of cells in each well being less than about 1,000, and exposing the cells in each well to a selected agent. The change in conductance in each well is determined by applying a low-voltage, AC signal across a pair of electrodes placed in that well, and synchronously measuring the conductance across the electrodes, to monitor the level of growth or metabolic activity of the cells in each well.

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