SRU Biosystems has been awarded US Patent 7,429,492, “Multiwell plates with integrated biosensors and membranes.”
The inventors listed on the patent are Bo Lin, Gangadhar Jogikalmath, Timothy Smith, Kurt Albertson, Christine Genick, and Lance Laing.
According to its abstract, the patent describes a multi-well plate comprising a colorimetric resonant reflectance biosensor or a grating-based waveguide biosensor; a first liquid impermeable sheet that has two or more holes attached to a top surface of the colorimetric resonant reflectance biosensor or the grating-based waveguide biosensor; a membrane attached to the top of the first liquid impermeable sheet, where the membrane covers all of the holes of the first liquid impermeable sheet; and a multi-well plate frame attached to the top of the membrane, where the multi-well plate frame has two or more holes and where the holes have a same size, number, and position as in the first liquid impermeable sheet. The colorimetric resonant reflectance biosensor or the grating-based waveguide biosensor, the first liquid impermeable sheet, the membrane, and the multiwell plate frame form a multi-well plate with an upper chamber and a lower chamber.
Galapagos has been awarded US Patent 7,429,459, “Methods for identifying a compound that inhibits the procession of amyloid-beta protein production in a mammalian cell expressing APP and overexpressing a G-protein coupled receptor in the cell.”
The inventors listed on the patent are Pascal Merchiers, Marcel Hoffmann, and Koenraad Spittaels.
The patent provides a method for identifying inhibitors of amyloidal-beta precursor protein processing in cells that comprises contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloidal-beta peptide. Cell-based assays using this method measure indicators such as second messenger and/or amyloid beta peptide levels.