Solidus Biosciences Thinks it Can Change ADME/Tox Screening; Hopes Pharma Agrees | GenomeWeb

Nascent biotechnology firm Solidus Biosciences is developing a cell-based assay chip that it says can perform rapid and inexpensive assessment of ADME/tox early on in the drug-development process, thereby eliminating unsuitable small-molecule candidates from further investigation.

The technology, which has been dubbed MetaChip, combines an array of sol-gel encapsulated cytochrome P450 metabolizing enzymes with a monolayer of cells on a micro-scale glass slide that can be read using any standard microarray scanner, fluorescent microscope, or combination thereof.

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