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Sigma-Aldrich s TargeTron Gene Knockout System, Celliance s Hybri-CYTE, and Peakdale Molecular s Peakexplorer GPCR Library


Sigma-Aldrich has announced the commercialization of the TargeTron Gene Knockout System. TargeTron provides a robust and simple method for site-specific disruption of DNA sequences within a host cell genome, Sigma-Aldrich said. The technology exploits the retrohoming ability of group II introns in order to “target” the exact position of gene disruption, the company said. The technology was developed by Alan Lambowitz from the University of Texas at Austin, and licensed from Ingex, Sigma-Aldrich said.

Celliance, a wholly owned subsidiary of Serologicals, has announced the introduction of Hybri-CYTE, a serum-free cell culture supplement designed and optimized for use in hybridoma cell culture. The supplement has been proven to work with mouse-, rat-, and rabbit-derived cell lines, Celliance said.

Peakdale Molecular has launched its fourth Peakexplorer GPCR library, featuring more than 1,100 compounds specifically designed, synthesized, and characterized for screening against GPCR targets. This latest library has been created through the assessment of seven chemotypes intended to target GPCRs, Peakdale said.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.