Scripps Team Seeks Oral Diabetes Drug, Focuses Search on GLP-1 Receptor | GenomeWeb
According to the American Diabetes Association, 20.8 million Americans, or 7 percent of the US population, have diabetes. In April 2005, the US Food and Drug Administration approved Amylin‘s Byetta (exenatide), a synthetic glucagon-like peptide 1 receptor analog, for the treatment of Type 2 diabetes mellitus.
 
Although exenatide is efficacious, it has pharmacokinetic and dosing limitations that if overcome, could add value to the discovery of small molecule, orally available GLP-1 agonists or potentiators.
 

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