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Roche Applied Science, AgenoLab, Promega, Leica

Roche Signs AgenoLab as First Customer for xCelligence Cell Analysis System
Roche Applied Science said this week that biotech services company AgenoLab has installed the xCelligence System, which Roche distributes through a partnership with Acea Biosciences.
Roche said Stuttgart, Germany-based AgenoLab purchased the xCelligence in April and installed it in July, making it the first customer to purchase the cell-based assay platform.
AgenoLab performs services in microbiology, molecular biology, cell culture technology, tissue engineering, and in other biomedical areas.
The system was originally developed by the San Diego-based Acea and was further developed with Roche as part of a marketing agreement the companies signed in November 2007 (see CBA News, 11/16/07).
Roche holds exclusive worldwide marketing rights to the technology.
The xCelligence platform is a label-free system that monitors cellular events in real time. It uses electrical impedance measurement to provide information about cell number, viability, and morphology.
Financial terms of the agreement with AgenoLab were not released.

Promega, Leica to Develop Fluorescent Proteins for Live-Cell Imaging
Promega said this week that it has signed an agreement with Leica Microsystems to develop fluorescent labels for proteins so that they can be visualized in live cells using a Leica super-resolution microscope.
Promega said it will develop fluorescent ligands for its HaloTag fusion proteins, which will be visualized within live cells using Leica’s TCS stimulated emission depletion, or STED, microscope.
Current fluorescent imaging methods, such as green fluorescent protein, are generally not optimal for use with STED technology, the company said, because they “are prone to photobleaching and lack appropriate spectral properties,” while other protein-labeling methods, such as fluorescent antibodies, are only applicable to fixed cells.
Promega said that the agreement with Leica will enable the imaging of proteins within live cells below the 100-nanometer range.

It added that it has been working with the imaging company since 2006 to develop novel ways to label proteins within cells.

The Scan

Two J&J Doses

Johnson & Johnson says two doses of its SARS-CoV-2 vaccine provides increased protection against symptomatic COVID-19, CNN reports.

Pfizer-BioNTech Vaccine Response in Kids

The Pfizer-BioNTech SARS-CoV-2 vaccine in a lower-dose format appears to generate an immune response among children, according to the Washington Post.

Chicken Changes to Prevent Disease

The Guardian writes that researchers are looking at gene editing chickens to help prevent future pandemics.

PNAS Papers on Siberian Dog Ancestry, Insect Reproduction, Hippocampal Neurogenesis

In PNAS this week: ancestry and admixture among Siberian dogs, hormone role in fruit fly reproduction, and more.