As high-content screening techniques continue to gain a foothold in pharmaceutical discovery programs, a debate is emerging: Which type of system is more suitable for drug-discovery applications — laser-based confocal platforms or lamp-based, non-confocal CCD camera imagers?

Now, scientists from Boehringer Ingelheim have added to the growing body of scientific literature comparing confocal and non-confocal imaging for specific high-content screens by publishing a paper comparing the technologies in a commonly used fluorescence translocation assay.

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