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Recent Cell-Based Assay Papers of Note: Jun 2, 2006

Recent Cell-Based Assay Papers of Note
Journal Title Lead Institution(s) Synopsis
Assay and Drug Development Technologies
2006 Apr; 4(2): 165-73
An innovative cell-based assay for the detection of modulators of soluble guanylate cyclase Axxam, Milan, Italy Describes a cell-based luminescent assay for 96- and 384-well plates to find modulators of soluble cellular guanylate cyclase
Assay and Drug Development Technologies
2006 Apr; 4(2): 133-141
A high-content screening assay for the Nogo receptor based on cellular Rho activation Abbot, Ludwigshafen, Germany Describes a high-content screening assay for potential Nogo receptor antagonists that uses HEK 293 cells that stably overexpress RhoA in the absence or presence of NgR
Assay and Drug Development Technologies
2006 Apr; 4(2): 143-152
A morphology- and kinetics-based cascade for human neural cell high-content screening Merck Sharp and Dohme Research Laboratories, Harlow, UK Describes a screen for stem cell behavior using human neural precursor cultures and two libraries of commercially available compounds
Assay and Drug Development Technologies
2006 Apr; 4(2): 153-163
The use of high-content screening for the discovery and characterization of compounds that modulate mitotic index and cell cycle progression by differing mechanisms of action Serenex, Durham, NC Validates an approach for characterizing inhibitors of Aurora kinase family members using high-content screening by determining compound effects on the levels of the mitotic marker phosphor-histone H3
Assay and Drug Development Technologies
2006 Apr; 4(2): 209-221
Application of laser-scanning fluorescence microplate cytometry in high-content screening TTP LabTech, Melbourn, UK Technology review focuses on the Acumen Explorer microplate cytometer and its use in high-content screening
BMC Cell Biology
2006 Apr 24; 7(1): 19
[Epub ahead of print]
Motion as a phenotype: The use of live-cell imaging and machine visual screening to characterize transcription-dependent chromosome dynamics Harvard Medical School, Boston Describes the use of a yeast strain that enables observation of the motion of the galactose-inducible GAL gene locus relative to the nuclear periphery in real time under transcriptionally active and repressed conditions
Current Opinions in Chemical Biology
2006 May 6;
[Epub ahead of print]
Small molecule screening by imaging Harvard Medical School, Boston Review article discusses the use of model organisms such as zebrafish in small-molecule screens, and the use of automated image analysis in such screens
Current Pharmaceutical Design
2006 May; 12(14): 1717-29
Integrative functional assays, chemical genomics, and high-throughput screening: Harnessing signal transduction pathways to a common HTS readout. Acadia Pharmaceuticals, San Diego Describes the Receptor Selection and Amplification Technology, a cell-based, high-throughput assay where receptor stimuli are translated into measurable cellular responses through an extensive signaling cascade over several days
Cytometry A
2006 May 5;
[Epub ahead of print]
Hyperchromatic cytometry principles for cytomics using slide based cytometry University of Leipzig, Germany Demonstrates various approaches for hyperchromatic cytometric analysis on a CompuCyte laser scanning cytometer
Cytometry A
2006 May 5;
[Epub ahead of print]
Object-oriented image analysis for high-content screening: Detailed quantification of cells and sub-cellular structures with the Cellenger software Definiens, Munich, Germany Technology review of Definiens' Cellenger high-content screening software using example of GFP signal discrimination in cells
2006 May; 87(5): 665-72
Functional screening for pro-apoptotic genes by reverse transfection cell array technology German Cancer Research Center, Heidelberg, Germany Describes the development of a screening assay based on reverse transfection of cellular arrays and subsequent analysis of cell morphology to identify pro-apoptotics genes
Journal of Clinical Virology
2006 May; 36(1): 50-9
Non-infectious fluorimetric assay for phenotyping of drug-resistant HIV proteinase mutants Institute of Organic Chemistry and Biochemistry, Academy of the Sciences of the Czech Republic, Prague Describes a non-infectious cell-based assay for quantifying drug resistance of HIV proteinase, an important target in highly active anti-retroviral therapy
Journal of Neuroscience Methods
2006 Jun 15; 153(2): 190-202
Computerized image analysis for quantitative neuronal phenotyping in zebrafish Harvard Medical School, Boston Describes the development of an integrated microscope image analysis pipeline for automatic analysis and phenotype quantification in zebrafish with altered expression of Alzheimer's disease-linked genes
The Scan

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Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

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Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.