Raven Biotechnologies has been awarded US Patent 7,462,487, “Cell culture media.”
The inventor listed on the patent is Mary Tsao.
The patent claims methods for culturing mammalian cells, preferably human cells, to improve production of recombinant or endogenous proteins, as stated in the abstract. Methods are also provided for the growth and long-term survival of cell lines, particularly cell lines established from primary culture. Cell culture media are described that contain varying levels of selected amino acids, supplemented with various growth factors and trace elements. The media are optionally serum free, and preferably use an energy source other than glucose. The media are particularly suitable for the primary and long-term culture of human fetal cells.