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Patent Watch: Jan 30, 2009

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SRU Biosystems has been awarded US Patent 7,483,127, “Method and apparatus for generating an image of biomolecular sensor target area.”

The inventor listed on the patent is Peter Li.

The patent claims a method and apparatus for imaging a target area. The apparatus comprises an adjustable light-emitting device that provides a light beam with a user-defined spectrum. A filter mechanism receives the light beam and directs it towards a target area. A device collects light reflected from a target area and generates an image from the light.


Phylonix Pharmaceuticals has been awarded US Patent 7,482,507, “Methods of screening agents for activity using teleosts.”

The inventors listed on the patent are George Serbedzija, Carlos Semino, and Deanna Frost.

The patent provides methods of screening an agent for activity using teleosts, as stated in the abstract. Methods of screening an agent for angiogenesis activity, toxic activity, and an effect cell death activity in teleosts are provided. The patent also provides high-throughput methods of screening agents in multi-well plates.


Cellomics (now part of Thermo Fisher) has been awarded US Patent 7,482,167, “Microbead-based test methods for fluorescence imaging systems.”

The inventors listed on the patent are Paul Sammak, Gustavo Rosania, Lawrence Zana, Kim Ippolito, Jason Bush, Alex Friedman, Sarah Burroughs Tencza, and Ravi Kapur.

According to the abstract, the patent describes a test plate and methods for adjusting fluorescence imaging systems that involve using a plate with fluorescent microbeads bound to a surface.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.