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Patent Watch: Jan 16, 2009

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Fisher BioImage, now part of Thermo Fisher Scientific, has been awarded US Patent 7,476,518, "Nucleic acids encoding fluorescent proteins and methods of using the same."

The inventors listed on the patent are Sara Petersen Bjorn, Len Pagliaro, and Ole Thastrup.

The patent claims a green fluorescent protein with an F64L mutation and an E222G mutation. This GFP has a bigger Stokes shift compared to other GFPs, which makes it appropriate for high-throughput screening due to a better resolution, according to the patent abstract. This GFP also has an excitation maximum between the yellow GFP and the cyan GFP, allowing for clearer band separation when used together with those GFPs.


Cellomics, now part of Thermo Fisher Scientific, has been awarded US Patent 7,476,510, "Miniaturized cell array methods and apparatus for cell-based screening."

The inventors listed on the patent are Ravi Kapur and Kenneth Giuliano.

As stated in its abstract, the patent provides methods and cassettes for cell-based toxin detection and organ localization. The cassettes includes an array containing cells and a matrix of openings or depressions, wherein each region of the substrate enclosed by the opening or depression in the matrix forms a domain that can be accessed by microfluidic channels in the device.

The Scan

Study Reveals New Details About Genetics of Major Cause of Female Infertility

Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency.

Circulating Tumor DNA Shows Potential as Biomarker in Rare Childhood Cancer

A study in the Journal of Clinical Oncology has found that circulating tumor DNA levels in rhabdomyosarcoma may serve as a biomarker for prognosis.

Study Recommends Cancer Screening for Dogs Beginning Age Seven, Depending on Breed

PetDx researchers report in PLOS One that annual cancer screening for dogs should begin by age seven.

White-Tailed Deer Harbor SARS-CoV-2 Variants No Longer Infecting Humans, Study Finds

A new study in PNAS has found that white-tailed deer could act as a reservoir of SARS-CoV-2 variants no longer found among humans.