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Patent Watch: Jan 16, 2009

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Fisher BioImage, now part of Thermo Fisher Scientific, has been awarded US Patent 7,476,518, "Nucleic acids encoding fluorescent proteins and methods of using the same."

The inventors listed on the patent are Sara Petersen Bjorn, Len Pagliaro, and Ole Thastrup.

The patent claims a green fluorescent protein with an F64L mutation and an E222G mutation. This GFP has a bigger Stokes shift compared to other GFPs, which makes it appropriate for high-throughput screening due to a better resolution, according to the patent abstract. This GFP also has an excitation maximum between the yellow GFP and the cyan GFP, allowing for clearer band separation when used together with those GFPs.


Cellomics, now part of Thermo Fisher Scientific, has been awarded US Patent 7,476,510, "Miniaturized cell array methods and apparatus for cell-based screening."

The inventors listed on the patent are Ravi Kapur and Kenneth Giuliano.

As stated in its abstract, the patent provides methods and cassettes for cell-based toxin detection and organ localization. The cassettes includes an array containing cells and a matrix of openings or depressions, wherein each region of the substrate enclosed by the opening or depression in the matrix forms a domain that can be accessed by microfluidic channels in the device.

The Scan

Not Yet a Permanent One

NPR says the lack of a permanent Food and Drug Administration commissioner has "flummoxed" public health officials.

Unfair Targeting

Technology Review writes that a new report says the US has been unfairly targeting Chinese and Chinese-American individuals in economic espionage cases.

Limited Rapid Testing

The New York Times wonders why rapid tests for COVID-19 are not widely available in the US.

Genome Research Papers on IPAFinder, Structural Variant Expression Effects, Single-Cell RNA-Seq Markers

In Genome Research this week: IPAFinder method to detect intronic polyadenylation, influence of structural variants on gene expression, and more.