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Panomics, MIT, Rigel Pharma, BioArray Solutions, UMich Awarded US Patents

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Panomics has been awarded US Patent No. 7,056,665, "Screening methods involving the detection of short-lived proteins."

Inventors listed on the patent are Xianqiang Li and Xin Jiang.

According to its abstract, the patent protects a method for screening for agents that affect protein degradation rates. The method comprises taking a library of cells in which the cells express a fusion protein comprising a reporter protein and a protein encoded by a varying sequence from a cDNA library derived from a sample of cells; contacting the cells with a plurality of agents that may affect protein degradation rates; for each agent, selecting cells that express short-lived proteins based on whether the cells have different reporter signal intensities than other cells, the difference being indicative of the selected cells expressing shorter lived fusion proteins than those expressed by other cells in the library; and characterizing the fusion proteins expressed by the selected cells for each agent.


The Massachusetts Institute of Technology has been awarded US Patent No. 7,056,683, "Genetically encoded fluorescent reporters of kinase, methyltransferase, and acetyl-transferase activities."

Alice Ting is the sole inventor listed on the patent.

According to its abstract, the patent protects fusion protein reporter molecules that can be used to monitor protein modifications (e.g., histone modifications) in living cells, and methods of using the reporter molecules for diagnosing protein modification-associated disorders (e.g. histone modification-associated disorders). The patent also describes methods of using the fusion protein reporters to identify candidate pharmaceutical agents that effect protein modification in cells and tissues, thus permitting identification of candidate agents for treating protein modification-associated disorders, the abstract states.


Rigel Pharmaceuticals has been awarded US Patent No. 7,056,687, "Methods and compositions for screening for altered cellular phenotypes."

Inventors listed on the patent are James Lorens, Todd Kinsella, Esteban Masuda, Yasumichi Hitoshi, Charlene Liao, Denise Pearsall, Annabelle Freiro, and Peter Chu.

According to its abstract, the patent protects methods and compositions useful for screening for altered cellular phenotypes using an inducible expression system to enrich for and detect the altered phenotypes. More particularly, the invention relates to screening libraries of candidate bioactive agents; for example, nucleic acids and peptides, in cells using a regulatable expression system to enrich for a subpopulation of cells having an altered phenotype due to the presence of a candidate bioactive agent, the abstract states.


The University of Michigan has been awarded US Patent No. 7,056,741, "Surface transfection and expression procedure."

Michael Uhler is the sole inventor listed on the patent.

According to its abstract, the patent protects a method of transfecting cells that comprises applying cells directly onto nucleic acids that are immobilized in transfection complexes on a surface and that transfect the cells. Preferably, the nucleic acids are immobilized in an array. In other aspects of the invention, the method includes expression of the nucleic acids in the transfected cells, and further comprises detecting the expression of the nucleic acids in the transfected cells, the abstract states.


BioArray Solutions has been awarded US Patent No. 7,056,746, "Array cytometry."

Inventors listed on the patent are Michael Seul and Alice Li.

According to its abstract, the patent protects a method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. The invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The invention also enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. Furthermore, the patent describes a method and apparatus to direct the lateral motion and induce the assembly into planar arrays of cells on semiconductor surfaces in response to temporally and spatially varying electric fields and to projected patterns of illumination, the abstract states.

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