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PamGene and the University of South Florida Awarded US Patents

PamGene has been awarded US Patent 7,419,778, “Method for high throughput cell-based assays using versatile living microarrays.”
Inventors listed on the patent are Hendrik Van Damme, Herman Blok, Maria Hilhorst, and Colin Ingham.
As stated in its abstract, the patent describes methods for screening the responses of cellular components comprising: (a) providing cellular components on the surface of a substrate on which an array of detector molecules has been immobilized; (b) delivering test compounds to positions on the substrate corresponding to the arrayed detector molecules on its surface; (c) incubating said test compounds with said cellular components on the surface of the solid support, under conditions allowing the induction of cellular responses; (d) assaying said cellular responses; and (e) identifying and characterizing the cellular responses induced by said test compounds. The patent also describes the uses of said methods as well as the necessary microarrays and kits.

The University of South Florida has been awarded US Patent 7,416,885, “Proliferated cell lines and uses thereof.”
The inventors listed on the patent are Thomas Freeman, Pablo Caviedes, and Raul Caviedes.
The patent discusses tumor cell lines that can be used to increase the proliferation potential of any human or animal cell in culture, according to its abstract. The patent also describes proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. A method for proliferating cells in culture by contacting cells with the proliferation factors is also provided. The proliferated cells can vary in plasticity and can include, for example, blast cells, fertilized ova, non-fertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. The cells can also be induced to cease proliferation. The proliferation cells of this invention are useful as in vitro models for research, toxicity testing, and drug development.

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