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Open Biosytems, Invitrogen, Caliper Life Sciences, Promega, BioFocus DPI, Genedata, IonGate, Millipore, CELLnTEC Advanced Cell Systems

Open Biosystems this week announced the availability of its Decode RNAi viral screening pools for multiplexed RNAi screens.
The first Decode RNAi viral screening set has been created using Open Biosystems' GIPZ lentiviral shRNAmir library and validated in its ability to produce effective knockdown even when expressed from a single integration event in target cells. This pooled screening set targets the entire human genome in a ready-to-use lentiviral pool format, extending RNAi screening to primary and non-dividing cells.
The Decode RNAi product will be expanded to include shRNAmir pools providing choices in promoters, fluorescent markers, and type of viral vector.

Invitrogen has launched ThiolTracker Violet, a thiol-reactive fluorescent probe that is appropriate for detecting intracellular reduced glutathione.
ThiolTracker Violet is applicable to a range of techniques including high-content imaging, flow cytometry, and fluorescent microscopy. The stain is permeable to live cells, yet survives formaldehyde fixation and detergent extraction. The company said that ThiolTracker Violet is 10 times brighter than conventional glutathione detection products.

Caliper Life Sciences has launched seven Bioware Ultra cell lines, the company announced this week. The cell lines cover a range of cancer models, including breast, colorectal, lung, and prostate cancers, as well as lymphoma.
The Bioware Ultra cell lines are available immediately.
The Bioware Ultra cell lines express an average of 1,000 photons/sec/cell. By tagging the cell lines with the luc2 gene from Promega, the cell lines produce light that can be monitored using Caliper’s IVIS imaging systems.
The luc2 gene is an optimized version of luciferase for expression in mammalian cells.
The company said that these cell lines are 10 to 100 times brighter than cell lines created using traditional methods, and allow researchers, for the first time ever, to detect a single cancer cell in an animal via non-invasive in vivo imaging.

BioFocus DPI recently launched its Intelligent Screening platform for drug discovery, the company said.
The manufacturer said that this approach combines the experience of BioFocus DPI’s scientists with high-throughput and high-content screening capabilities to support partners’ drug discovery programs.
The Intelligent Screening approach calls upon: PrimePath, BioFocus DPI’s compound screening service that uses disease-relevant complex assays in human primary cells; its high-throughput and high-content ion channel screening capabilities; and its natural product screening platform. In addition, these services are complemented by BioFocus DPI’s screening libraries.

Genedata has released Screener 5.5, its new solution for high-throughput and high-content screening analysis, the company said recently.
Screener 5.5 features integration of pharmacological fit models and advanced functionality for analyzing experiments with multiple readouts. In addition, Screener’s open and scalable architecture extends its applicability as an enterprise screening analysis platform from ultra high-throughput screening to therapeutics, and provides access to a range of information in corporate research and drug discovery systems.

IonGate plans to launch its SURFE2R Workstation 5000 by the end of the year, the company recently announced.
The SURFE2R 5000 is the latest version of IonGate’s SURFE2R technology. It is a direct functional assay for screening transport proteins. The workstation comprises a standard laptop connected to a central unit equipped with a sensor plate holder, a low-noise eight-channel amplifier, and an IonJet 8 functional head for liquid handling. Assay reagents and test compounds are also stored on-station.
IonJet 8 is IonGate’s newly-developed functional head for liquid handling.

Millipore has released of a new range of primary human epithelial cells, the company announced this week. Developed by CELLnTEC Advanced Cell Systems, these epithelial cell cultures are made available by Millipore as part of a partnership agreement signed in 2006.
Supplied as complete kits including specialized media for their propagation, these primary cell cultures provide an enriched population of progenitor cells from skin, cornea, and bladder epithelia. 
The new cells display extended longevity due to their isolation in CELLnTEC’s Progenitor Cell Targeted media formulations, Millipore said. PCT culture media are developed to specifically mimic the environment of the stem cell.

The Scan

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.

Coronary Artery Disease Risk Loci, Candidate Genes Identified in GWAS Meta-Analysis

A GWAS in Nature Genetics of nearly 1.4 million coronary artery disease cases and controls focused in on more than 200 candidate causal genes, including the cell motility-related myosin gene MYO9B.

Multiple Sclerosis Contributors Found in Proteome-Wide Association Study

With a combination of genome-wide association and brain proteome data, researchers in the Annals of Clinical and Translational Neurology tracked down dozens of potential multiple sclerosis risk proteins.

Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations

With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan.