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Open Biosystems

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Open Biosystems this week announced the availability of its Expression Arrest GIPZ lentiviral shRNAmir libraries.
 
According to the company, the libraries consist of shRNAmir constructs targeting the entire human genome that have been pre-cloned into the GIPZ lentiviral vector.
 
The constructs are available individually now. Family/pathway and whole genome collections are expected to be available in January 2007, the company said.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.