Odyssey Thera has been awarded US Patent No. 6,929,916, "Protein fragment complementation assays for the detection of biological or drug interactions."
Inventors listed on the patent are Stephen Michnick, Joelle Pelletier, and Ingrid Remy.
According to its abstract, the patent protects a method for detecting biomolecular interactions, the method comprising: (a) selecting an appropriate reporter molecule from the group consisting of a protein, a fluorescent protein, a luminescent protein, and a phosphorescent protein; (b) effecting fragmentation of said reporter molecule such that said fragmentation results in reversible loss of reporter function; (c) fusing or attaching fragments of said reporter molecule separately to other molecules; followed by (d) re-association of said reporter fragments through interactions of the molecules that are fused to said fragments; and (e) detecting said biomolecular interactions by reconstitution of activity of the reporter molecule with the proviso that said protein is not ubiquitin.
The University of California has been awarded US Patent No. 6,929,925, "Assays for sensory modulators using a sensory cell-specific G-protein beta subunit."
Inventors listed on the patent are Charles Zuker, Jon Adler, and Juergen Lindemeier.
According to its abstract, the patent protects nucleic acid and amino acid sequences of sensory-specific G-protein beta subunits that are specifically expressed in sensory cells; antibodies to such subunits; methods of detecting such nucleic acids and proteins; and methods of screening for modulators of sensory cell specific beta subunits.
Imperial College Innovations has been awarded US Patent No. 6,929,934, "Optical microscopy and its use in the study of cells."
Inventors listed on the patent are Yuri Korchev, David Klenerman, and Max Lab.
According to its abstract, the patent protects an apparatus for imaging an object, the instrument comprising a probe via which an assay component may be delivered; a sensor to detect ion current; and means for controlling the position of the probe relative to the object in response to the ion current. Such an apparatus can be used to image live cells, without affecting them, in solution, e.g., using light, wherein the distance between probe and cell is less than the wavelength of light, the abstract states.
Molecular Devices has been awarded US Patent No. 6,930,314, "Light detection device."
Inventors listed on the patent are Joseph Jackson, Dean Hafeman, and Todd French.
According to its abstract, the patent protects an apparatus and methods for optical illumination and/or detection with improved flexibility and/or read speed. The apparatus and methods may include mechanisms for selecting and switching between multiple excitation wavelengths and/or simultaneously reading from a plurality of sample sites, the abstract states. The apparatus and methods may be used with microplates, PCR plates, cell culture plates, biochips, chromatography plates, microscope slides, and other substrates for high-throughput screening, genomics, SNP analysis, pharmaceutical research and development, life sciences research, and other applications, the abstract states.
Temple University has been awarded US Patent No. 6,933,128, "Cell-based assay for screening cox-2 inhibitors."
Inventors listed on the patent are Premkumar Reddy, Ramana Reddy, and Natarajan Dhanasekaran.
According to its abstract, the patent protects a cell-based assay for screening substances for the capacity to inhibit COX-2 activity. The assay utilizes as a screening reagent a cell line which has been engineered to achieve constitutive or inducible expression of COX-2, the abstract states. In one embodiment, the cells express a GTPase-deficient, constitutively-activated mutant form of the a-subunit of protein G12, which induces the production of arachidonic acid and COX-2. Decreased cell proliferation in the presence of test substance indicates that the substance has COX-2 inhibitory activity, the abstract states.