Odyssey Thera has been awarded US Patent 7,306,914, “Protein fragment complementation assays in whole animals applications to drug efficacy, ADME, cancer biology, immunology, infectious disease, and gene therapy.”
The inventors listed on the patent are Stephen Michnick, Marnie MacDonald, and John Westwick.
The invention describes a method for detecting protein-protein interactions in living organisms and/or cells, the patent abstract said. The technique comprises: synthesizing probe protein fragments from a protein, which enables fluorescent or luminescent detection by dissecting the gene encoding the protein into a least two fragments; constructing fusion proteins consisting of the probe protein fragments linked to protein domains that are to be tested for interactions; co-expression of the fusion proteins; and detecting reconstitution of the fluorescence or luminescence signal.
New York University has been awarded US Patent 7,306,905, “Method of identifying substances useful for promoting resistance to cell stress.”
The inventors listed on the patent are David Ron and Heather Harding.
According to its abstract, the patent discusses methods for identifying test substances useful for the prevention or treatment of diseases involving an oxidative stress. The techniques involve screening assays, including high-throughput screening methods, in which the substances under study are tested for their ability to promote resistance to oxidative stress by activating one or more steps along the integrated stress response pathway, while not causing stress.