NeuroNova has been awarded US Patent 7,320,872, “Ependymal neural stem cells and method for their isolation.”
The inventors listed on the patent are Ann Marie Janson, Jonas Frisen, Clas Johansson, Stefan Momma, Diana Clarke, Ming Zhao, Urban Lendahl, and Kioumars Delfani.
According to the abstract, the patent describes an ependymal neural CNS stem cell, which expresses the surface protein Notch 1 together with at least one surface protein chosen from the group of Notch 2, Notch 3, CAR (transmembrane protein binding adenovirus), and CFTR (cystic fibrosis transmembrane conductance regulator). The cell also comprises at least one cilium. The patent also describes preparations, including pharmaceutical preparations, comprising ependymal neural CNS stem cells; in vitro and in vivo assays based on these cells; and various other uses of the cells.