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National Institutes of Health and Norak Biosciences and AstraZeneca

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NIH to Award $2M in FY 2005 for Predictive ADME-Tox

The National Institutes of Health has issued a request for applications for new methods for predicting ADME-Tox profiles.

The project, “Novel Preclinical Tools for Predictive ADME-Toxicology,” is an NIH Roadmap initiative.

NIH said that it intends to commit around $2 million in fiscal year 2005 to fund four to seven new grants in response to the RFA.

Examples of preclinical ADME-Tox evaluation tools that will be considered for awards include statistical models developed from preclinical and available clinical data; computational models, including data integration tools that link mRNA levels, protein expression levels, protein activities, and metabolite profiles with chemical scaffolds and ADME-tox parameters; quantitative structure-activity relationship models; and experimental methods.

Letters of intent are due on Dec. 17, and applications are due on Jan. 21, 2005.


Norak Signs Second Transfluor Licensing Agreement with AZ

Norak Biosciences said last week that it has signed a second license agreement with AstraZeneca to continue the use of Transfluor fluorescence assays in AZ’s G-protein coupled receptor drug-discovery program.

AstraZeneca will use Transfluor to advance novel lead compounds discovered in a primary high-throughput screen using Transfluor under an agreement signed in June 2002, Norak said. The terms of that agreement called for Norak to develop a cell line for an AZ GPCR target of interest that was subsequently screened by AZ.

Financial terms of the deal were not disclosed.

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.