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Nagoya University, Japan Science and Technology Agency, Dainippon Sumitomo Pharma Company, Eppendorf Array Technologies Awarded US Patents

Nagoya University has been awardedUS Patent 7,407,797, “Apparatus for monitoring bioluminescence of biological samples.”
The inventors listed on the patent are Masahiro Ishiura, Kazuhisa Okamoto, Kiyoshi Onai, and Takayoshi Furusawa.
According to its abstract, the patent describes an apparatus for monitoring the bioluminescence of organism samples comprising a cell culture component that includes multiple plates in which to culture multiple organism samples, and that is also capable of cultivating these samples; a monitoring component for monitoring the bioluminescence of the samples; a means to convey the plates to the monitoring component; a component for controlling the movement of the plates and the monitoring of the bioluminescence; and a computer for recording and analyzing data.

The Japan Science and Technology Agency and Dainippon Sumitomo Pharma Company have been awarded US Patent 7,407,766, “Screening method for agonists or antagonists of semaphorin 6C by determining the effect of a test compound on the interaction between semaphorin 6C and plexin-A1.”
The inventors listed on the patent are Hajime Fujisawa, Toru Kimura, Kaoru Kikuchi, and Yasunori Murakami.
As stated in the abstract, the patent provides screening methods for agonists or antagonists of Sema6C using Plexin-A1, and tools for the screening. The evaluation will be carried out by the connectivity of a protein having an extracellular domain of Semaphorin 6C, a growth cone collapse activity of Plexin-A1 expressing cell, or a contractile activity of Plexin-A1 expressing cell.

Eppendorf Array Technologies has been awarded US Patent 7,407,748, “Method and kit for the determination of cellular activation profiles.”
The inventors listed on the patent are Jose Remacle, Patricia Renard, and Muriel Art.
According to its abstract, the patent describes a method for obtaining an activation profile of a biological sample comprising disposing onto a solid support in a pre-determined spatial arrangement a subset of capture molecules able to interact with one or more activated transcription factor(s) present in the biology cell sample; contacting the biological sample upon the solid support under conditions allowing their interaction; monitoring signals resulting from their interaction; and providing a cellular activation profile from the detected signals.

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