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Nagoya University, CyBio, Arctic Diagnostics, Ramon Mohanlal

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Nagoya University of Nagoya, Japan, has been awarded US Patent 7,199,378, “Method for measuring and analyzing bioluminescence and device for measuring and analyzing bioluminescence.”
 
Inventors listed on the patent are Masahiro Ishiura and Kazuhisa Okamoto.
 
The patent covers a method for measuring and analyzing bioluminescence, including the steps of receiving in real time a luminescence measurement result group from a sample group, displaying and maintaining in real time the luminescence measurement result group, receiving in real time another luminescence measurement result group from the sample group, and displaying and maintaining in real time another luminescence measurement result group, instead of the luminescence measurement result group.
 

 
CyBio of Jena, Germany, has been awarded US Patent 7,199,377, “Optical analytic measurement device for fluorescence measurements in multisample carriers.”
 
Inventors listed on the patent are Juergen Wulf, Eberhard Dietzsch, and Thomas Moore.
 
The invention covers a device for optical analytic measurement in a multisample carrier, “particularly for measuring fluorescence or bioluminescence,” the patent abstract states. The excitation light from a light source is directed on the multisample carrier coaxially in a ring-shaped manner around an optical axis, which is oriented in direction normal to the multisample carrier and coaxial to the direction of the readout beam path. A ring mirror unit with at least one curved ring mirror is arranged coaxial to the optical axis in such a way that the excitation light illuminates the multisample carrier homogeneously on all sides at an oblique incident angle.
 

 
Arctic Diagnostics of Turku, Finland, has been awarded US Patent 7,198,958, “Method for increasing hydrophilicity of fluorescent label compounds.”
 
Inventors listed on the patent are Niko Meltola and Aleksi Soini.
 
The patent protects a fluorescent label compound that includes a reactive group that can be used for covalent coupling of the fluorescent label compound to other molecules. The patent also describes the use of the compounds in bioanalytical assays and cytological or histological staining methods, and a method for increasing the hydrophilicity of fluorescent compounds.
 

 
Ramon Mohanlal of Boston, Mass., has been awarded US Patent 7,198,895, “In vitro cell-based methods for biological validation and pharmacological screening of chemical entities and biologicals.
 
This patent describes an in vitro cell-based method for biological validation and pharmacological screening of drugs, new chemical entities, and biologics. The method is predictive for efficacy and adverse events in patients, according to the patent abstract. The approach can also be used to identify new indications for existing medicines and new indications for NCEs that were unsuccessful in their intended uses.

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