MIT Assay Measures Cytoskeletal Forces; Observed Protein Bonds May Be Rx Targets | GenomeWeb
Researchers at the Massachusetts Institute of Technology have used optical tweezers to develop a native-like assay that can test the rupture force of a complex formed by an actin-binding protein linking two quasiparallel actin filaments.
 
The assay enabled the researchers to observe ABP unfolding and conformational transition events, suggesting that both may play a significant role in the temporal regulation of the mechanical properties of the actin cytoskeleton.
 

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