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Millipore, GE Healthcare, Thermo Fisher Scientific, MaxCyte, PerkinElmer

Millipore this week announced the release of a cell culture medium for generating three-dimensional, in vivo-like, epidermal keratinocyte models. Developed by CELLnTEC Advanced Cell Systems, this epidermal keratinocyte 3D medium is made available by Millipore as part of a partnership agreement signed in 2006.
In the past, the preparation of 3D epidermal in vitro models has been left primarily to specialized commercial providers. Labs choosing to prepare their own models have often struggled with complicated protocols and the use of culture media designed for cell isolation and proliferation, rather than the specific demands of a 3D model requiring complete differentiation.
To fill this void, CELLnTEC developed a new 3D-optimized medium, which along with CELLnTEC primary human keratinocytes and Millicell inserts from Millipore, can be used to cost-effectively and routinely establish 3D epidermal models, the company said.
CELLnTEC’s new 3D epidermal keratinocyte medium was optimized for use with CELLnTEC’s human primary keratinocytes which, when combined with Millipore’s Millicell inserts, create an experimental system for 3D in vitro skin modeling.

GE Healthcare this week introduced IN Cell Miner High-Content Manager for managing data generated by cellular high-content screening and analysis systems. The client-server-based application handles data that has been generated by the IN Cell Analyzer imaging system.
The IN Cell Miner HCM is fully aligned with the IN Cell Analyzer HCA system and the IN Cell Investigator image-analysis software.
The IN Cell Miner HCM system uses a data-management platform provided by EMC Documentum

Thermo Fisher Scientific this week introduced the Nunc UpCell surface for temperature-induced cell harvesting. The Nunc UpCell surface is available as sterile MicroWell plates, dishes, and multi-dishes, all with a certificate stating conformance to functional, sterility, non-pyrogenic and toxicity tests.
According to the manufacturer, the UpCell surface negates the need for trypsinization and cell scraping. It consists of a covalently-immobilized polymer poly(N-isopropylacrylamide), or PIPAAm, which forms a thin, even layer on the culture dish or plate. The surface allows cells to attach and grow, because it is slightly hydrophobic at 37°C. However, when the temperature is reduced to below 32°C, the surface becomes hydrophilic, and will bind water and swell, resulting in the release of adherent cells with their underlying extracellular matrix.
The retention of the ECM under the cells enables the harvesting of contiguous cell sheets with preserved cell polarization and cell-cell junctions, and the attachment of one cell sheet to another cell sheet or a graft site without the use of fibrin glue or sutures. 3-D tissue models and co-cultures can thus be created without scaffolds and exogenous materials, the company said.

Thermo Fisher Scientific also introduced this week the Nunc HydroCell surface for cultivating single cells and cell clusters in suspension. Designed to prevent cell attachment, the Nunc HydroCell surface allows scientists to grow suspension cells that are sensitive to unwanted activation and differentiation signals arising from cell adhesion.
In addition, the adsorption of culture medium-derived proteins and cell-secreted proteins to the Nunc HydroCell surface is minimal, the company said.
The Nunc HydroCell Surface is a thin layer of a covalently-immobilized super hydrophilic polymer, and is available as sterile MicroWell plates, dishes, and multi-dishes.

MaxCyte announced this week that it would launch the MaxCyte STX scalable transfection system this week at the Society for Biomolecular Sciences meeting in King of Prussia, Pa. 
"We believe that the MaxCyte STX scalable transfection system addresses many of these challenges [in cell-based assays], including reducing the time and expense to develop relevant assays for high-throughput screening,” Madhusudan Peshwa, vice president of research and development at MaxCyte, said in a statement. “The MaxCyte STX technology enables the large-scale transfection of primary cells, cell lines, and stem cells with multiple loading agents at the same time, resulting in more relevant screening systems."

PerkinElmer Life and Analytical Sciences, this week launched the Columbus high-content screening data management system, a platform for archiving, managing, retrieving, and protecting images and analyzed results. The company introduced the platform during a symposium at the Society for Biomolecular Sciences meeting held this week in King of Prussia, Pa.
Designed as a partner product for PerkinElmer's confocal microplate imaging reader, the Opera, the Columbus software is fully compatible with a wide range of image file formats, the company said. The Columbus software can be used to archive and manage images from confocal and standard research microscopes, and act as a central repository for all image data.
The Columbus data management platform uses an open protocol, run on the OMERO server developed by the Open Microscopy Environment, a multi-site collaborative effort among academic laboratories and a number of commercial entities that produces open tools to support data management for biological light microscopy. By using an open protocol, the Columbus software is interoperable with a wide variety of instruments and software, with support being added for more products on a frequent basis.
The Columbus data management software is available in two versions: Columbus Gallery, which provides a comprehensive data archive, management and visualization solution, and Columbus Conductor, that includes all the functionality of Columbus Gallery, plus the ability to analyze or re-analyze HCS data from the Opera imaging reader or other image data using PerkinElmer’s Acapella image-analysis software.  

The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.