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Millipore, DiscoverX, Immunicon

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Millipore this week launched a set of AdenoSilence adenoviral shRNA expression vectors targeting the human druggable genome. Millipore said that the classes included in this release represent all of the major protein classes amenable to small-molecule intervention, including kinases, GPCRs, ion channels, proteases, nuclear hormone receptors, secreted proteins, and receptors.
 
The AdenoSilence vectors are available in three different sequence variants, and are sold individually or as a kit containing all three. The product is a result of a distribution agreement announced this year between Millipore and BioFocus, the drug-discovery service division of Galapagos.
 

 
DiscoverX this week said that it has expanded its cell-based PathHunter β-arrestin assays to include 45 validated cell products, each expressing a different Gi-, Gs-, or Gq-coupled receptor.
 
PathHunter β-arrestin assays are the first chemiluminescent GPCR assays that measure activation of Gi-, Gs-, or Gq-coupled receptor signaling by direct arrestin recruitment, as opposed to a second messenger, the company said.
 

 
Immunicon this week launched the EasyCount System, a fluorescent microscopy-based imaging system for counting dead and live nucleated cells, and calculating cell viability in a single test.
 
Immunicon said that researchers can perform as many as six tests at a time using the EasyCount Slide6 multi-well slide that is provided with the EasyCount ViaSure kit. The instrument can report total and live cell counts and calculate viability in less than one minute per test, Immunicon said.

The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.