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Metabolon, Cytokinetics, UC, Li-Cor, Amnis Among Recent US Patent Winners

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Metabolon has been awarded US Patent No. 7,005,255, "Methods for drug discovery, disease treatment, and diagnosis using metabolomics."

Inventors listed on the patent are Rima Daouk-Kaddurah and Bruce Kristal.

According to its abstract, the patent protects methods in which the small molecule profiles of cells are compared to identify small molecules that are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are also discussed, the abstract states.


Cytokinetics has been awarded US Patent No. 7,005,272, "Methods for screening and therapeutic applications of kinesin modulators."

Roman Sakowicz is the lone inventor listed on the patent.

According to its abstract, the patent protects protein modulators, especially modulators of kinesin bioactivities. The patent also provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bioactivities. The patent also describes methods and compositions for treatment of disorders mediated by abnormal cellular proliferation activities, the abstract states.


The University of California has been awarded US Patent No. 7,005,511, "Fluorescent protein variants and methods for making same."

Inventors listed on the patent are Roger Tsien, Robert Campbell, and Geoffrey Baird.

According to its abstract, the patent protects variant fluorescent proteins; more specifically, monomeric and dimeric forms of Anthozoan fluorescent proteins. In one aspect, the invention provides variants of fluorescent proteins, where the variants have a reduced propensity to tetramerize, and form dimeric or monomeric structures. The invention also relates to methods of making and using such fluorescent protein monomers and dimers, the abstract states.


Li-Cor has been awarded US Patent No. 7,005,518, "Phthalocyanine dyes."

Inventors listed on the patent are Xinzhan Peng, Daniel Draney, and Jiyan Chen.

According to its abstract, the patent protects fluorescent dyes that are useful as reporter groups for labeling biomolecules. The silicon phthalocyanine dyes described are preferably water soluble, isomerically pure, possess high quantum yield, and are useful in bioassays, the abstract states.


Technology Innovations has been awarded US Patent No. 7,006,219, "Biological imager."

David Prelewitz is the lone inventor listed on the patent.

According to its abstract, the patent protects an apparatus and method for quantifying the biological components of a biological system having at least two different refractive indices through detection of wavefront distortions. The biological component fractions are determined based on information gathered on their respective indices when exposed to particular wavelengths of light, the abstract states.


Amnis Corporation has been awarded US Patent No. 7,006,710, "Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging."

Inventors listed on the patent are James Riley and Keith Frost.

According to its abstract, the patent protects a method and apparatus for correcting crosstalk and spatial resolution in a multichannel imaging system that generates an ensemble of images for each field of view of an object. Each image in the ensemble is intended to contain information from only one source among a plurality of sources for the object. However, due to crosstalk, at least a portion of the signal from a first source appears in a channel intended for a second source. Because the accuracy of the correction will be degraded if the images in an ensemble are spatially misaligned with respect to one another, the spatial offset between images is determined and a correction is applied to substantially eliminate the offset. Then, a correction to the signals is determined to substantially reduce the contributions to the signal in a channel from the signals in other channels. The signal processing can be employed to process the output signals for each of a plurality of different disclosed imaging systems, the abstract states.

The Scan

PLOS Papers on Methicillin-Resistant Staphylococcus, Bone Marrow Smear Sequencing, More

In PLOS this week: genomic analysis of methicillin-resistant Staphylococcus pseudintermedius, archived bone marrow sequencing, and more.

Shape of Them All

According to BBC News, researchers have developed a protein structure database that includes much of the human proteome.

For Flu and More

The Wall Street Journal reports that several vaccine developers are working on mRNA-based vaccines for influenza.

To Boost Women

China's Ministry of Science and Technology aims to boost the number of female researchers through a new policy, reports the South China Morning Post.