Merck: Multiplexed Imaging, Transfluor Beats FLIPR at Predicting GPCR Activity | GenomeWeb
Researchers at Merck Research Laboratories have found that a multiplexed Transfluor assay sold by Molecular Devices provides more detailed information than the firm’s fluorometric imaging plate reader, and is more predictive of a compound’s antagonistic activity at the level of receptor-ligand interaction, versus the FLIPR assay.
 
The researchers multiplexed the Transfluor assay with an immunofluorescence-based quantification of G protein-coupled receptor internalization to screen approximately 2,000 compounds.

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