Merck’s New Genome-Wide RNAi Screen T’fection May Help Uncover Reliable Hits | GenomeWeb
A team of researchers at Merck has developed a genome-wide RNAi screening technique that may increase the dynamic range and decrease the variability in cell-based assays used for RNAi screening, which could facilitate reliable hit selection, according to their findings.
 
The investigators showed that the method, called T’fection, yielded a mean absolute deviation-based hit selection that identified physiologically relevant false negatives that standard-deviation-based methods missed.
 

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