Memory Pharmaceuticals has been awarded US Patent 7,358,057, “QM-7 and QT-6 cells transfected with mutant cell surface expressed channel receptors and assays using the transfected cells.”
The inventors listed on the patent are Daguang Wang and Michael De Vivo.
The patent describes QM-7 or QT-6 cells comprising a heterologous mutant nicotinic α7 acetylcholine receptor and/or a nucleic acid encoding it, the abstract said. These QM-7 and QT-6 cells are useful for assays such as high-throughput assays that measure the influx of cations into a cell.
Monogram Biosciences has been awarded US Patent 7,358,052, “Catalytic amplification of multiplexed assay signals.”
The inventor listed on the patent is Sharat Singh.
Its abstract said that the patent describes methods, compositions, kits, and a system for detecting one or more analytes in a sample. A mixture comprising the sample; a first binding reagent comprising a cleavage-inducing moiety and a first binding agent specific for an analyte; and one or more electrophoretic probes, each having a second binding agent, is subjected to conditions under which binding of respective binding agents occurs. The interaction between the binding agents and the analyte brings the cleavage-inducing moiety close enough to cleave the linkage tethering an electrophoretic tag to the second binding agent, thereby releasing the tag for electrophoretic separation. Separation of different tags occurs because of their distinct electrophoretic mobilities. After separation, a signal amplification moiety on each tag is activated to generate a signal to indicate the presence of a particular analyte.