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LJL Biosystems, PDD, and Imaging Research Awarded US Patents

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LJL Biosystems has been awarded US Patent No. 6,806,053, “Cell-signaling assays.”

Inventors listed on the patent are: Richard Sportsman and Lawrence Kauvar.

According to its abstract, the patent describes assays for detecting the presence and activity of cell-signaling components. The assays include luminescence polarization assays for detecting cell-signaling nucleotides, and modulators of receptors and enzymes related to the generation and activity of such nucleotides, the abstract states.


Pharmacopeia Drug Discovery has been awarded US Patent No. 6,806,056, “Fluorescent capture assay for kinase activity employing and anti-phosphotyrosine antibody as both the capture agent and detecting agent.”

Inventors listed on the patent are: Fraser Glickman, James Inglese, Bassam Damaj, Maria Webb, and Jonathan Burbaum.

According to its abstract, the patent discloses a method for determining the level of tyrosine kinase activity in a biological sample. The method employs an anti-phosphotyrosine antibody as both the capture agent and the detecting agent, the abstract states. The detecting antibody is labeled with a fluorescent label, for instance, Cy5, Cy5.5 or Cy7 or a lanthanide ion, such as europium, as the signal generating entity. The method is particularly well-suited to high throughput screening, for example, for compounds which modulate tyrosine kinase activity, the abstract states.


Imaging Research has been awarded US Patent No. 6,806,455, “Imaging fluorometer for time-resolved fluorescence.”

Inventors listed on the patent are: Carlos Zarate, Paul Donders, Ahmad Yekta, Zahra Masoumi, and Peter Ramm.

According to its abstract, the patent describes an apparatus and method for imaging time-resolved fluorescence in biochemical and medical samples. In a primary aspect, the device includes a lens of large aperture, a flash lamp in the illumination path, a fast-acting solid state shutter, or a gated detector in the emission path; a device for delivering homogenous monochromatic illumination to a plurality of wells distributed within a microwell plate; a digital camera of high quantum efficiency; and a computer, the abstract states. Under computer control, the lamp is pulsed at short intervals, and the fast-acting emission shutter or gated detector operates to limit exposure of the camera to a period some microseconds after the extinction of each lamp pulse, during which only delayed fluorescence is transmitted to the camera. The invention achieves simultaneous time-resolved imaging of a plurality of samples, with high sensitivity and high throughput, the abstract states.

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