Kimberly-Clark Worldwide has been awarded US Patent 7,439,079, “Assay devices having detection capabilities within the hook effect region.”
The inventors listed on the patent are Xuedong Song and Paul Christopher.
According to its abstract, the patent provides a lateral flow assay device for detecting the presence or quantity of an analyte within a test sample. The device uses multiple zones, one of which serves as an indicator of whether or not the analyte in the test sample is within the "hook effect" region. Based on this indication, a technique may be selected for correlating a measured signal intensity to an analyte concentration or range of concentrations. For example, when it is determined that the test sample falls outside the "hook effect" region, the analyte concentration may be determined using one portion of a dose-response curve. On the other hand, when it is determined that the test sample falls within the "hook effect" region, the analyte concentration may be determined using another portion of the dose-response curve. Alternatively, the sample may simply be diluted for re-performing the assay.
Vanderbilt University has been awarded US Patent 7,439,039, “Assays for novel serotonin transporter (SERT) blockers.”
The inventors listed on the patent are Randy Blakely, Loren Henry, and Erika Adkins.
The serotonin transporter is a target of various therapeutic agents used to treat neurological and neurodegenerative disorders. The patent provides novel forms of SERT that lack high-affinity recognition of selective serotonin reuptake inhibitors, as stated in the patent’s abstract. The present invention therefore provides a novel target for use in screening and model development that can aid both the discovery of new medications and the discovery of novel pathways impacted in parallel with SERT blockade. Such novel targets can help identify new SSRIs with unique modifications, and lead to the discovery of pathways that secondarily support the therapeutic activity of these agents.